Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases

Milisav, Irina (author), Šuput, Dušan (author), Ribarič, Samo (author)

Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.

• Language: English
• Keywords: Alzheimer's disease, autophagy, Parkinson's disease, neurodegeneration, prion diseases, proteostasis, unfolded protein response
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine; ZF - Faculty of Health Sciences
• Publication status: Published
• Publication version: Version of Record
• Year: 2015
• Number of pages: Str. 22718-22756
• Numbering: Vol. 20, iss. 12
• PID: 20.500.12556/RUL-130385
• UDC: 616-092
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules201219865
• COBISS.SI-ID: 32400601
• Publication date in RUL: 14.09.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 18.12.2015

Secondary language

• Language: Slovenian
• Keywords: Alzheimerjeva bolezen, avtofagija, Parkinsonova bolezen

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0171
• Name: Plastičnost živčevja v fizioloških in patofizioloških razmerah

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0019
• Name: Aplikativna in bazična fiziologija in patofiziologija v medicini