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Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases
ID Milisav, Irina (Author), ID Šuput, Dušan (Author), ID Ribarič, Samo (Author)

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Abstract
Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.

Language:English
Keywords:Alzheimer's disease, autophagy, Parkinson's disease, neurodegeneration, prion diseases, proteostasis, unfolded protein response
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
ZF - Faculty of Health Sciences
Publication status:Published
Publication version:Version of Record
Year:2015
Number of pages:Str. 22718-22756
Numbering:Vol. 20, iss. 12
PID:20.500.12556/RUL-130385 This link opens in a new window
UDC:616-092
ISSN on article:1420-3049
DOI:10.3390/molecules201219865 This link opens in a new window
COBISS.SI-ID:32400601 This link opens in a new window
Publication date in RUL:14.09.2021
Views:1598
Downloads:163
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Record is a part of a journal

Title:Molecules
Shortened title:Molecules
Publisher:MDPI
ISSN:1420-3049
COBISS.SI-ID:18462981 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:18.12.2015

Secondary language

Language:Slovenian
Keywords:Alzheimerjeva bolezen, avtofagija, Parkinsonova bolezen

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P3-0171
Name:Plastičnost živčevja v fizioloških in patofizioloških razmerah

Funder:ARRS - Slovenian Research Agency
Project number:P3-0019
Name:Aplikativna in bazična fiziologija in patofiziologija v medicini

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