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Genetska pestrost nukleotidnega zaporedja kodogenih regij proteina ACE2 pri prašiču (Sus scrofa)
ID Arnšek, Tina (Author), ID Dovč, Peter (Mentor) More about this mentor... This link opens in a new window

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Abstract
Decembra 2019 se je v mestu Wuhan na Kitajskem pojavil novi betakoronavirus, SARS-CoV-2, povzročitelj koronavirusne bolezni 2019 (COVID-19). SARS-CoV-2 je tretji zoonotski človeški koronavirus v tem stoletju, ki je povzročil epidemijo. SARS-CoV-2 za vstop v gostiteljske celice z receptor vezavno domeno na S proteinu prepoznajo receptor ACE2 (angiotenzin konvertaza 2) na celicah gostitelja. SARS-CoV-2 se lahko prenaša tudi s človeka na žival. Primarna struktura ACE2 kaže na veliko podobnost aminokislinskega zaporedja pri človeku in različnih živalskih vrstah. Zaradi podobnosti tarčnih proteinov za vezavo virusa SARS-CoV-2 s tarčnimi proteini človeka, nekatere vrste domačih živali predstavljajo potencialni rezervoar za razmnoževanje virusa in lahko povzročijo (ponovno) razširjanje okužb v človeški populaciji. Določila sem nukleotidno zaporedje, ki zapisuje ACE2 receptor nekaterih krškopoljskih prašičev, in poskušala napovedati, ali lahko predstavljajo potencialni rezervoar za SARS-CoV-2. Ugotovila sem, da se ACE2 receptorji krškopoljskih prašičev od človeškega ACE2 razlikujejo v nekaterih ključnih aminokislinah, na katere se veže SARS-CoV-2, in zato najverjetneje niso v veliki nevarnosti za okužbo s tem virusom.

Language:Slovenian
Keywords:ACE2, SARS-CoV-2, zoonoza
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2021
PID:20.500.12556/RUL-130167 This link opens in a new window
COBISS.SI-ID:83298819 This link opens in a new window
Publication date in RUL:10.09.2021
Views:835
Downloads:94
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Secondary language

Language:English
Title:Genetic variability of coding regions for ACE2 protein in pig (Sus scrofa)
Abstract:
In December 2019, a new betacoronavirus, SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), appeared in Wuhan, China. SARS-CoV-2 is the third zoonotic human coronavirus in this century to cause an epidemic. For entry into host cells SARS-CoV-2 recognizes the ACE2 receptor (angiotensin-converting enzyme 2) on host cells via the receptor binding domain of the S protein. SARS-CoV-2 can also be transmitted from human to animal. The primary structure of ACE2 displays very high amino acid sequence similarity in humans and different animal species. Due to the similar target proteins for SARS-CoV-2 virus binding to human target proteins, some domestic animal species represent a potential reservoir for virus replication and may cause (re) spread of infection in the human population. I determined the DNA sequence of the ACE2 receptor of several krškopoljski pigs, and tried to predict whether they might represent a potential reservoir for SARS-CoV-2. I have found that ACE2 receptors in krškopoljski pigs differ from human ACE2 in some of the key amino acids to which SARS-CoV-2 binds, and therefore are most likely not at high risk for infection with this virus.

Keywords:ACE2, SARS-CoV-2, zoonosis

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