Adaptive response, evidence of cross-resistance and its potential clinical use

Milisav, Irina (author), Poljšak, Borut (author), Šuput, Dušan (author)

Organisms and their cells are constantly exposed to environmental fluctuations. Among them are stressors, which can induce macromolecular damage that exceeds a set threshold, independent of the underlying cause. Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli. Different stressors or different intensities of stress trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc. These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.

• Language: English
• Keywords: oxidative stress, stress, adaptation, adaptive response, preconditioning, pretreatment, hormesis, autophagy, apoptosis, anti-apoptosis, environmental exposure, autophagocytosis, eukaryotic cells, DNA damage, DNA repair, macromolecular systems, antioxidants, reactive oxygen species
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine; ZF - Faculty of Health Sciences
• Publication status: Published
• Publication version: Version of Record
• Year: 2012
• Number of pages: Str. 10771-10806
• Numbering: Vol. 13, iss. 9
• PID: 20.500.12556/RUL-129510
• UDC: 616-092
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms130910771
• COBISS.SI-ID: 30114777
• Publication date in RUL: 03.09.2021

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 3.0, Creative Commons Attribution 3.0 Unported
• Link: https://creativecommons.org/licenses/by/3.0/deed.en
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
• Licensing start date: 01.09.2012

Secondary language

• Language: Slovenian
• Keywords: adaptacija, avtofagocitoza, okoljska izpostavljenost, oksidativni stres, apoptoza, poškodbe DNA, antioksidanti, evkariontske celice, aktivne oblike kisika, makromolekularni sistemi, obnova DNA

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0019
• Name: Aplikativna in bazična fiziologija in patofiziologija v medicini