Electroporation is a physical method that allows the passage of many molecules through the cell membrane that is impermeable to this very molecules. Using short, high-voltage electrical pulses in the plasma membrane causes the formation of hydrophilic pores. Membrane electroporation can either be reversible (cell membrane reseal) or irreversible (cell membrane cannot return to its primary state and cell death occurs). Electroporation has many possible applications in several areas. It is used for cell fusion, water sterilization, food pasteurization, substance extraction, transfection, transformation, etc. Electroporation has also gained a place in medicine, especially in the field of cancer treatment. For this purpose, reversible electroporation is used to introduce cytostatic into cancer cells. When electroporation is used, the efficiency of cisplatin increases 70 times and the efficiency of bleomycin up to 700 times. We can also use irreversible electroporation, where we kill cancer cells, for non-thermal ablation of tissues and tumors.
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