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Bacteriophage delivery systems based on composite polyHIPE/nanocellulose hydrogel particles
ID Kopač, Tilen (Author), ID Lisac, Ana (Author), ID Mravljak, Rok (Author), ID Ručigaj, Aleš (Author), ID Krajnc, Matjaž (Author), ID Podgornik, Aleš (Author)

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Abstract
The role of bacteriophage therapy in medicine has recently regained an important place. Oral phage delivery for gastrointestinal treatment, transport through the stomach, and fast release in the duodenum is one of such applications. In this work, an efficient polyHIPE/hydrogel system for targeted delivery of bacteriophages with rapid release at the target site is presented. T7 bacteriophages were encapsulated in low crosslinked anionic nanocellulose-based hydrogels, which successfully protected phages at pH < 3.9 (stomach) and completely lost the hydrogel network at a pH above 3.9 (duodenum), allowing their release. Hydrogels with entrapped phages were crosslinked within highly porous spherical polyHIPE particles with an average diameter of 24 µm. PolyHIPE scaffold protects the hydrogels from mechanical stimuli during transport, preventing the collapse of the hydrogel structure and the unwanted phage release. On the other hand, small particle size, due to the large surface-to-volume ratio, enables rapid release at the target site. As a consequence, a fast zero-order release was achieved, providing improved patient compliance and reduced frequency of drug administration. The proposed system therefore exhibits significant potential for a targeted drug delivery in medicine and pharmacy.

Language:English
Keywords:TEMPO nanocellulose, T7 bacteriophage, encapsulation, drug diffusion, zero-order release
Work type:Article (dk_c)
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2021
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:12 str.
Numbering:Vol. 13, iss. 16, art. 2648
PID:20.500.12556/RUL-129027 This link opens in a new window
UDC:678:615:578.81
ISSN on article:2073-4360
DOI:10.3390/polym13162648 This link opens in a new window
COBISS.SI-ID:73830403 This link opens in a new window
Publication date in RUL:24.08.2021
Views:427
Downloads:132
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Record is a part of a journal

Title:Polymers
Shortened title:Polymers
Publisher:Molecular Diversity Preservation International
ISSN:2073-4360
COBISS.SI-ID:517951257 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:09.08.2021

Secondary language

Language:Slovenian
Keywords:TEMPO nanoceluloza, bakteriofag T7, inkapsulacija, difuzija učinkovin, sproščanje ničtega reda

Projects

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J2-9440
Name:Karakterizacija fraktalnih struktur in povečevalni kriteriji njihove sinteze

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J7-2603
Name:Učinkovitost bakteriofagov za zdravljenje ekstracelularnih in intracelularnih bakterijskih okužb implantatov

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P1-0153
Name:Raziskave in razvoj analiznih metod in postopkov

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P2-0191
Name:Kemijsko inženirstvo

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