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Towards personalized and versatile monitoring of temperature fields within heterogeneous tissues during laser therapies
ID Košir, Jure (Author), ID Vella, Daniele (Author), ID Lukač, Matjaž (Author), ID Jezeršek, Matija (Author)

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Abstract
Advancements in medical laser technology have paved the way for its widespread acceptance in a variety of treatments and procedures. Selectively targeting particular tissue structures with minimally invasive procedures limits the damage to surrounding tissue and allows for reduced post-procedural downtime. In many treatments that are hyperthermia-based, the efficiency depends on the achieved temperature within the targeted tissues. Current approaches for monitoring subdermal temperature distributions are either invasive, complex, or offer inadequate spatial resolution. Numerical studies are often therapy-tailored and source tissue parameters from the literature, lacking versatility and a tissue-specific approach. Here, we show a protocol that estimates the temperature distribution within the tissue based on a thermographic recording of its surface temperature evolution. It couples a time-dependent matching algorithm and thermal-diffusion-based model, while recognizing tissue-specific characteristics yielded by a fast calibration process. The protocol was employed during hyperthermic laser treatment performed ex-vivo on a heterogeneous porcine tissue, and in-vivo on a human subject. In both cases the calibrated thermal parameters correlate with the range of values reported by other studies. The matching algorithm sufficiently reproduced the temperature dynamics of heterogeneous tissue. The estimated temperature distributions within ex-vivo tissue were validated by simultaneous reference measurements, and the ones estimated in-vivo reveal a distribution trend that correlates well with similar studies. The presented method is versatile, supported by the protocol for tissue-specific tailoring, and can readily be implemented for temperature monitoring of various hyperthermia-based procedures by means of recording the surface temperature evolution with a miniature thermal camera implemented within a handheld laser scanner or similar.

Language:English
Keywords:temperature measurement, laser medical procedures, process monitoring
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FS - Faculty of Mechanical Engineering
Publication status:Published
Publication version:Version of Record
Year:2021
Number of pages:Str. 4530-4543
Numbering:Vol. 12, no. 7, art. 428028
PID:20.500.12556/RUL-128832 This link opens in a new window
UDC:535
ISSN on article:2156-7085
DOI:10.1364/BOE.428028 This link opens in a new window
COBISS.SI-ID:72307459 This link opens in a new window
Copyright:
"© 2021 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved." (Datum opombe: 27. 3. 2023)
Publication date in RUL:05.08.2021
Views:883
Downloads:169
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Record is a part of a journal

Title:Biomedical optics express
Shortened title:Biomed. opt. express
Publisher:Optica
ISSN:2156-7085
COBISS.SI-ID:24857383 This link opens in a new window

Secondary language

Language:Slovenian
Keywords:merjenje temperature, laserske terapije, nadzor procesa

Projects

Funder:Other - Other funder or multiple funders
Funding programme:Ministrstvo za izobraževanje, znanost in šport
Project number:C3330-16-529000
Name:GOSTOP

Funder:ARRS - Slovenian Research Agency
Project number:P2-0392
Name:Optodinamika

Funder:ARRS - Slovenian Research Agency
Project number:L2-1833
Name:Lasersko vzbujena podpovršinska mikrodestrukcija tkiva (LasDes)

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