Relationship between circulating vascular endothelial growth factor and its soluble receptor in patients with hemorrhagic fever with renal syndrome
ID Pal, Emil (Author), ID Korva, Miša (Author), ID Resman Rus, Katarina (Author), ID Kejžar, Nataša (Author), ID Bogovič, Petra (Author), ID Strle, Franc (Author), ID Avšič-Županc, Tatjana (Author)

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Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2) in HFRS patients infected with Dobrava (DOBV) or Puumala virus (PUUV). VEGF and sVEGFR-2 levels were measured in daily plasma and urine samples of 73 patients with HFRS (58 with PUUV, 15 with DOBV) and evaluated in relation to clinical and laboratory variables. In comparison with the healthy controls, initial samples (obtained in the first week of illness) from patients with HFRS had higher plasma and urine VEGF levels, whereas sVEGFR-2 levels were lower in plasma but higher in urine. VEGF levels did not differ in relation to hantavirus species, viral load, or the severity of HFRS. The comparison of VEGF dynamics in plasma and urine showed the pronounced secretion of VEGF in urine. Significant correlations were found between daily VEGF/sVEGFR-2 levels and platelet counts, as well as with diuresis: the correlations were positive for plasma VEGF/sVEGFR-2 levels and negative for urine levels. In addition, patients with hemorrhagic manifestations had very high plasma and urine VEGF, together with high urine sVEGFR-2. Measuring the local secretion of sVEGFR-2 in urine might be a useful biomarker for identifying HFRS patients who will progress to severe disease.

Keywords:hemorrhagic fever, vascular endothelial growth factor, soluble receptor
Work type:Article (dk_c)
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:9 str.
Numbering:Vol. 7, art. 89
ISSN on article:2222-1751
DOI:10.1038/s41426-018-0090-5 This link opens in a new window
COBISS.SI-ID:33775577 This link opens in a new window
V datoteki založnikove različice članka (PDF) je dodana uvodna stran, na kateri je kot založnik naveden Taylor and Francis. V samem članku je kot založnik naveden Nature (v glavi prve strani) oz. Springer Nature (na predzadnji strani pod naslovom Publisher's note). Pristajalna stran članka (URL) sodi med spletne strani založnika Taylor and Francis. (28. 7. 2021)
Publication date in RUL:26.07.2021
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Record is a part of a journal

Title:Emerging microbes & infections
Shortened title:Emerg. microbes & infect.
Publisher:Springer Nature
COBISS.SI-ID:523072793 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:16.05.2018

Secondary language

Keywords:hemoragična mrzlica, vaskularni endotelijski rastni faktor, topni receptor


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:P3-0083
Name:Odnosi parazitskega obstajanja

Funder:Drugi - Drug financer ali več financerjev
Funding programme:U.S. Civilian Research and Development Foundation
Project number:SIB1-2964-LJ-09

Funder:EC - European Commission
Funding programme:H2020
Project number:653316
Name:European Virus Archive goes global

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