Two-photon retinal theranostics by adaptive compact laser source
Podlipec, Rok (Author), Mur, Jaka (Author), Petelin, Jaka (Author), Štrancar, Janez (Author), Petkovšek, Rok (Author)

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To avoid a devastating effect of eye vision impairment on the information flow from the eye to our brain, enormous effort is being put during the last decades into the development of more sensitive diagnostics and more efficient therapies of retinal tissue. While morphology can be impressively imaged by optical coherence tomography, molecular-associated pathology information can be provided almost exclusively by auto-fluorescence-based methods. Among the latter, the recently developed fluorescence lifetime imaging ophthalmoscopy (FLIO) has the potential to provide both structural information and interacting pictures at the same time. The requirements for FLIO laser sources are almost orthogonal to the laser sources used in phototherapy that is expected to follow up the FLIO diagnostics. To make theranostics more effective and cheaper, the complete system would need to couple at least the modalities of low-power high-repetition-rate FLIO and precision high-pulse energy-adjustable repetition rate phototherapy. In addition, the intermediate-power high repetition rate for two-photon excitation would also be desired to increase the depth resolution. In our work, compact fiber-laser based on high-speed gain-switched laser diode has been shown to achieve adaptable/independently tunable repetition rate and energy per pulse allowing coupled fluorescence lifetime diagnostics via two-photon excitation and phototherapy via laser-induced photodisruption on a local molecular environment in a complex ex vivo retinal tissue.

Keywords:adaptable fiber lasers, retinal tissue, theranostics, multimodal imaging, fluorescence lifetime imaging
Work type:Article (dk_c)
Tipology:1.01 - Original Scientific Article
Organization:FS - Faculty of Mechanical Engineering
Number of pages:Str. 1-9
Numbering:Vol. 126, art. 405, iss. 6
ISSN on article:0947-8396
DOI:10.1007/s00339-020-03587-2 This link opens in a new window
COBISS.SI-ID:14993923 This link opens in a new window
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Record is a part of a journal

Title:Applied physics
Shortened title:Appl. phys., A, Mater. sci. process.
COBISS.SI-ID:14196007 This link opens in a new window

Document is financed by a project

Funder:Drugi - Drug financer ali več financerjev
Funding Programme:Republika Slovenija, Ministrstvo za izobraževanje, znanost in šport
Name:Gradniki, orodja in sistemi za tovarne prihodnosti

Funder:EC - European Commission
Funding Programme:European Union – European Regional Development Fund
Name:Building Blocks, Tools and Systems for the Factories of the Future

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:L7-7561
Name:Mikrospektroskopska karakterizacija in optimizacija učinka laserskih sunkov na očesni mrežnici

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:L2-9240
Name:Ultrakratki laserski pulzi na zahtevo

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:L2-9254
Name:Prostorsko in časovno oblikovanje laserske svetlobe za minimalno invazivne oftalmološke posege

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P2-0270
Name:Proizvodni sistemi, laserske tehnologije in spajanje materialov

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P1-0060
Name:Eksperimentalna biofizika kompleksnih sistemov in slikanje v biomedicini

Secondary language

Keywords:prilagodljivi vlakenski laserji, tkivo mrežnice, teranostika, multimodalno slikanje, življenjski čas fluorescence

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