Let the biocatalyst flow

Žnidaršič Plazl, Polona (author)

Industrial biocatalysis has been identified as one of the key enabling technologies that, together with the transition to continuous processing, offers prospects for the development of cost-efficient manufacturing with high-quality products and low waste generation. This feature article highlights the role of miniaturized flow reactors with free enzymes and cells in the success of this endeavor with recent examples of their use in single or multiphase reactions. Microfluidics-based droplets enable ultrahigh-throughput screening and rapid biocatalytic process development. The use of unique microreactor configurations ensures highly efficient contacting of multiphase systems, resulting in process intensification and avoiding problems encountered in conventional batch processing. Further integration of downstream units offers the possibility of biocatalyst recycling, contributing to the cost-efficiency of the process. The use of environmentally friendly solvents supports effective reaction engineering, and thus paves the way for these highly selective catalysts to drive sustainable production.

• Language: English
• Keywords: flow biocatalysis, microflow reactor, ionic liquids, aqueous two-phase systems, microreactor, continuous process, process intensification, process integration
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: Str. 1-16
• Numbering: Vol. 68, no. 1
• PID: 20.500.12556/RUL-127094
• UDC: 66.098
• ISSN on article: 1580-3155
• DOI: 10.17344/acsi.2020.6488
• COBISS.SI-ID: 47790851
• Publication date in RUL: 17.05.2021

Record is a part of a journal

• Title: Acta chimica slovenica
• Shortened title: Acta chim. slov.
• Publisher: Slovensko kemijsko društvo, =Slovenian Chemical Society
• ISSN: 1580-3155
• COBISS.SI-ID: 21870085

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 20.01.2021

Secondary language

• Language: Slovenian
• Keywords: biokataliza, mikropretočni reaktorji, ionske kapljevine, dvofazni vodni sistem, mikroreaktor, kontinuirni proces, postopek intenzivnosti, integracija procesov