Let the biocatalyst flow
ID Žnidaršič Plazl, Polona (Author)

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Industrial biocatalysis has been identified as one of the key enabling technologies that, together with the transition to continuous processing, offers prospects for the development of cost-efficient manufacturing with high-quality products and low waste generation. This feature article highlights the role of miniaturized flow reactors with free enzymes and cells in the success of this endeavor with recent examples of their use in single or multiphase reactions. Microfluidics-based droplets enable ultrahigh-throughput screening and rapid biocatalytic process development. The use of unique microreactor configurations ensures highly efficient contacting of multiphase systems, resulting in process intensification and avoiding problems encountered in conventional batch processing. Further integration of downstream units offers the possibility of biocatalyst recycling, contributing to the cost-efficiency of the process. The use of environmentally friendly solvents supports effective reaction engineering, and thus paves the way for these highly selective catalysts to drive sustainable production.

Keywords:flow biocatalysis, microflow reactor, ionic liquids, aqueous two-phase systems, microreactor, continuous process, process intensification, process integration
Work type:Article
Typology:1.02 - Review Article
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:Str. 1-16
Numbering:Vol. 68, no. 1
PID:20.500.12556/RUL-127094 This link opens in a new window
ISSN on article:1580-3155
DOI:10.17344/acsi.2020.6488 This link opens in a new window
COBISS.SI-ID:47790851 This link opens in a new window
Publication date in RUL:17.05.2021
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Record is a part of a journal

Title:Acta chimica slovenica
Shortened title:Acta chim. slov.
Publisher:Slovensko kemijsko društvo, =Slovenian Chemical Society
COBISS.SI-ID:21870085 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:20.01.2021

Secondary language

Keywords:biokataliza, mikropretočni reaktorji, ionske kapljevine, dvofazni vodni sistem, mikroreaktor, kontinuirni proces, postopek intenzivnosti, integracija procesov


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P2-0191
Name:Kemijsko inženirstvo

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:N2-0067
Name:Večstopenjska sinteza z MIO-encimi v kontinuirnem mikroreaktorskem sistemu

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J4-1775
Name:Razvoj mikropretočnih sistemov za analizo, izbor in uporabo bakterijskih celic

Funder:EC - European Commission
Funding programme:H2020
Project number:811040
Name:Chair Of Micro Process Engineering and TEchnology

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