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Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis
Dogša, Iztok (Author), Špacapan, Mihael (Author), Dragoš, Anna (Author), Danevčič, Tjaša (Author), Pandur, Žiga (Author), Mandić-Mulec, Ines (Author)

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Abstract
Bacterial quorum sensing (QS) is based on signal molecules (SM), which increase in concentration with cell density. At critical SM concentration, a variety of adaptive genes sharply change their expression from basic level to maximum level. In general, this sharp transition, a hallmark of true QS, requires an SM dependent positive feedback loop, where SM enhances its own production. Some communication systems, like the peptide SM-based ComQXPA communication system of Bacillus subtilis, do not have this feedback loop and we do not understand how and if the sharp transition in gene expression is achieved. Based on experiments and mathematical modeling, we observed that the SM peptide ComX encodes the information about cell density, specific cell growth rate, and even oxygen concentration, which ensure power-law increase in SM production. This enables together with the cooperative response to SM (ComX) a sharp transition in gene expression level and this without the SM dependent feedback loop. Due to its ultra-sensitive nature, the ComQXPA can operate at SM concentrations that are 100–1000 times lower than typically found in other QS systems, thereby substantially reducing the total metabolic cost of otherwise expensive ComX peptide.

Language:English
Keywords:bacterial physiology, microbial ecology
Work type:Article (dk_c)
Tipology:1.01 - Original Scientific Article
Organization:FS - Faculty of Mechanical Engineering
Year:2021
Number of pages:Str. 1-12
Numbering:Vol. 4
UDC:579.22/.26:579.852.1
ISSN on article:2399-3642
DOI:10.1038/s42003-020-01553-5 This link opens in a new window
COBISS.SI-ID:47412483 This link opens in a new window
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Downloads:84
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Record is a part of a journal

Title:Communications biology
Shortened title:Commun. biolog.
Publisher:Springer Nature
ISSN:2399-3642
COBISS.SI-ID:5134671 This link opens in a new window

Document is financed by a project

Funding Programme:Vesna Vogrič and Martina Vrhar
Name:initial protocol development for ComX measurements and isolation

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:J4-9302
Name:Raziskave medceličnih komunikacij v večceličnih skupnostih različnih izolatov bakterije iz rodu Bacillus

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:P4-0116
Name:Mikrobiologija in biotehnologija živil in okolja

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Funding Programme:University infrastructural center “Microscopy of biological samples”

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.04.2021

Secondary language

Language:Slovenian
Keywords:Bacillus subtilis, komunikacija med celicami, zaznavanje kvoruma, signalni peptidi

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