Does the urothelium of old mice regenerate after chitosan injury as quickly as the urothelium of young mice?
ID Erzar, Eva (Author), ID Kerec Kos, Mojca (Author), ID Lakota, Katja (Author), ID Veranič, Peter (Author), ID Erman, Andreja (Author)

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The aging of organisms leads to a decreased ability of tissue to regenerate after injury. The regeneration of the bladder urothelium after induced desquamation with biopolymer chitosan has been studied in young mice but not in old mice. Chitosan is a suitable inducer of urothelial desquamation because it is known to be non-toxic. We used chitosan for desquamation of urothelial cells in order to compare the dynamics of urothelial regeneration after injury between young and old mice. Our aim was to determine whether the urothelial function and structure of old mice is restored as fast as in young mice, and to evaluate the inflammatory response due to chitosan treatment. We discovered that the urothelial function restored comparably fast in both age groups and that the urothelium of young and old mice recovered within 5 days after injury, although the onset of proliferation and differentiation appeared later in old mice. Acute inflammation markers showed some differences in the inflammatory response in young versus old mice, but in both age groups, chitosan caused short-term acute inflammation. In conclusion, the restoration of urothelial function is not impaired in old mice, but the regeneration of the urothelial structure in old mice slightly lags behind the regeneration in young mice.

Keywords:urothelium, young mice, old mice, chitosan, regeneration, inflammation
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Number of pages:23 str.
Numbering:Vol. 21, iss. 10, art. 3502
PID:20.500.12556/RUL-125369 This link opens in a new window
ISSN on article:1422-0067
DOI:10.3390/ijms21103502 This link opens in a new window
COBISS.SI-ID:16463875 This link opens in a new window
Publication date in RUL:12.03.2021
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Record is a part of a journal

Title:International journal of molecular sciences
Shortened title:Int. j. mol. sci.
COBISS.SI-ID:2779162 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:15.05.2020

Secondary language

Keywords:urotelijskih celice, hitosan, vnetni odgovor, mlade miši, regeneracija urotelija


Funder:ARRS - Slovenian Research Agency
Project number:P3-0108
Name:Diferenciacija urotelijskih celic

Funder:ARRS - Slovenian Research Agency
Project number:P1-0189
Name:Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

Funder:ARRS - Slovenian Research Agency
Project number:P3-0314
Name:Sistemske avtoimunske bolezni

Funder:ARRS - Slovenian Research Agency
Project number:I0-0022
Name:Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)

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