DPP-4 inhibitors in the prevention/treatment of pulmonary fibrosis, heart and kidney injury caused by covid-19-a therapeutic approach of choice in type 2 diabetic patients?

Smelcerović, Andrija (author), Kocic, Gordana (author), Gajic, Mihajlo (author), Tomović, Katarina (author), Djordjevic, Vukica (author), Stankovic-Djordjevic, Dobrila (author), Anderluh, Marko (author)

Since the outbreak of SARS-CoV-2 virus more than 12,500,000 cases have been reported worldwide. Patients suffering from diabetes and other comorbidities are particularly susceptible to severe forms of the COVID-19, which might result in chronic complications following recovery. Dipeptidyl peptidase-4 inhibitors exert beneficial effects in prevention/treatment of pulmonary fibrosis, heart, and kidney injury, and since they may be a long-term consequence caused by COVID-19, it is reasonable to expect that DPP-4 inhibitors might be beneficial in alleviating long-term consequences of COVID-19. With that in mind, we would like to voice our concerns over chronic implications following recovery from COVID-19, especially not only in diabetic but also in non-diabetic patients, and to indicate that some preventive measures could be undertaken by application of DPP-4 inhibitors.

• Language: English
• Keywords: COVID-19, diabetes, DPP-4 inhibitors, fibrosis, multi-organ injury
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 4 str.
• Numbering: Vol. 11, art. 1185
• PID: 20.500.12556/RUL-124557
• UDC: 616.9+616.2
• ISSN on article: 1663-9812
• DOI: 10.3389/fphar.2020.01185
• COBISS.SI-ID: 25125123
• Publication date in RUL: 02.02.2021

Record is a part of a journal

• Title: Frontiers in pharmacology
• Shortened title: Front Pharmacol
• Publisher: Frontiers Media
• ISSN: 1663-9812
• COBISS.SI-ID: 29551833

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 02.02.2021

Secondary language

• Language: Slovenian
• Keywords: COVID-19, poškodbe notranjih organov, korona virus, DPP-4 zaviralci, pljučna fibroza