Healthy lifestyle recommendations : do the beneficial effects originate from NAD + amount at the cellular level?

Poljšak, Borut (author), Kovač, Vito (author), Milisav, Irina (author)

In this review, we describe the role of oxidized forms of nicotinamide adenine dinucleotide (NAD+ ) as a molecule central to health benefits as the result from observing selected healthy lifestyle recommendations. Namely, NAD+ level can be regulated by lifestyle and nutrition approaches such as fasting, caloric restriction, sports activity, low glucose availability, and heat shocks. NAD+ is reduced with age at a cellular, tissue, and organismal level due to inflammation, defect in NAMPT-mediated NAD+ biosynthesis, and the PARP-mediated NAD+ depletion. This leads to a decrease in cellular energy production and DNA repair and modifies genomic signalling leading to an increased incidence of chronic diseases and ageing. By implementing healthy lifestyle approaches, endogenous intracellular NAD+ levels can be increased, which explains the molecular mechanisms underlying health benefits at the organismal level. Namely, adherence to here presented healthy lifestyle approaches is correlated with an extended life expectancy free of major chronic diseases.

• Language: English
• Keywords: nicotinamide adenine dinucleotide, NAD+, health benefits, molecular mechanisms, healthy lifestyle
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: ZF - Faculty of Health Sciences
• Year: 2020
• Number of pages: Str. 1-12
• Numbering: Vol. 2020
• PID: 20.500.12556/RUL-124548
• UDC: 612.68:613
• ISSN on article: 1942-0994
• DOI: 10.1155/2020/8819627
• COBISS.SI-ID: 49263107
• Publication date in RUL: 01.02.2021

Record is a part of a journal

• Title: Oxidative medicine and cellular longevity
• Shortened title: Oxid. med. cell. longev.
• Publisher: Hindawi
• ISSN: 1942-0994
• COBISS.SI-ID: 29264601

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.02.2021

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0388
• Name: Mehanizmi varovanja zdravja