Your browser does not allow JavaScript!
JavaScript is necessary for the proper functioning of this website. Please enable JavaScript or use a modern browser.
Open Science Slovenia
Open Science
DiKUL
slv
|
eng
Search
Browse
New in RUL
About RUL
In numbers
Help
Sign in
The effects of feed naturally contaminated with Fusarium mycotoxins on the thymus in suckling piglets
ID
Ujčič Vrhovnik, Igor
(
Author
),
ID
Švara, Tanja
(
Author
),
ID
Malovrh, Tadej
(
Author
),
ID
Jakovac-Strajn, Breda
(
Author
)
This document has no files that are freely available to the public.
This document may have a phisical copy in the library of the organization, check the status via
COBISS.
Image galllery
Abstract
In this study, feed naturally containing Fusarium mycotoxins was fed to gilts during the perinatal period, and the effects on the thymus were investigated in one-week-old piglets. Twenty gilts were divided into equal control (0.26 mg deoxynivalenol, DON) and experimental (5.08 mg DON, 0.09 mg zearalenone and 21.61 mg fusaric acid per kg of feed) groups. One suckling piglet from each litter (n = 20) was sacrificed at one week of age to obtain thymus samples for further analysis. The cortex to medulla ratio of the thymus was morphometrically analysed using NIS Elements BR (Nikon) software. Paraffin-embedded thymus sections were stained to quantify apoptosis (with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling – TUNEL method), cellular proliferation (Ki-67) and macrophages (MAC 387). The results showed that the thymus cortex (P = 0.023) to medulla (P = 0.023) ratio was significantly lower in the experimental group. The number of apoptotic cells (cortex, P = 0.010, medulla, P = 0.001) and the number of proliferating cells in the thymus cortex (P = 0.001) and medulla (P < 0.001) were significantly higher in the experimental group. Our results indicate that feeding Fusarium mycotoxins to a parent animal during the perinatal period induces significant alterations in the thymus of one-week-old piglets, which indicates an immunosuppressive effect in piglets.
Language:
English
Keywords:
Fusarium
,
mycotoxins
,
piglets
,
thymus
,
sdverse effects
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
VF - Veterinary Faculty
Publication status:
Published
Publication version:
Author Accepted Manuscript
Year:
2020
Number of pages:
Str. 186-192
Numbering:
Vol. 68, no. 2
PID:
20.500.12556/RUL-124476
UDC:
636.4.09:615.9
ISSN on article:
0236-6290
DOI:
10.1556/004.2020.00030
COBISS.SI-ID:
48426755
Publication date in RUL:
25.01.2021
Views:
918
Downloads:
15
Metadata:
Cite this work
Plain text
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Copy citation
Share:
Record is a part of a journal
Title:
Acta veterinaria Hungarica
Shortened title:
Acta Vet. Hung.
Publisher:
Akadémiai Kiadó
ISSN:
0236-6290
COBISS.SI-ID:
610170
Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:
25.01.2021
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P4-0092
Name:
Zdravje živali, okolje in varna hrana
Similar documents
Similar works from RUL:
Similar works from other Slovenian collections:
Back