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Pharmacokinetics of carprofen in anaesthetized pigs : a preliminary study
ID
Bošnjak, Maša
(
Author
),
ID
Kržan, Mojca
(
Author
),
ID
Lampreht Tratar, Urša
(
Author
),
ID
Dolenc, Jožica
(
Author
),
ID
Čemažar, Maja
(
Author
),
ID
Seliškar, Alenka
(
Author
)
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https://www.sciencedirect.com/science/article/pii/S1467298720302270?via%3Dihub
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Abstract
Objective To investigate the pharmacokinetics of carprofen after a single intravenous (IV) dose and multiple oral doses administered to pigs undergoing electroporation of the pancreas. Study design Prospective experimental study. Animals A group of eight female pigs weighing 31.74 ± 2.24 kg (mean ± standard deviation). Methods Carprofen 4 mg kg−1 was administered IV after placement of a central venous catheter during general anaesthesia with isoflurane. Blood samples were collected 30 seconds before and 5, 10, 20, 30 and 60 minutes and 2, 4, 6, 8, 12 and 24 hours after carprofen administration. Subsequently, the same dose of carprofen was administered orally, daily, for 6 consecutive days and blood collected at 36, 48, 60, 72, 96, 120, 144 and 168 hours after initial carprofen administration. Plasma was analysed using liquid chromatography with mass spectrometry. Standard pharmacokinetic parameters were calculated by compartmental analysis of plasma concentration–time curves. Data are presented as mean ± standard error. Results The initial plasma concentration of IV carprofen was estimated at 54.57 ± 3.92 μg mL−1 and decreased to 8.26 ± 1.07 μg mL−1 24 hours later. The plasma elimination curve showed a bi-exponential decline: a rapid distribution phase with a distribution half-life of 0.21 ± 0.03 hours and a slower elimination phase with an elimination half-life of 17.31 ± 3.78 hours. The calculated pharmacokinetic parameters were as follows: the area under the plasma concentration–time curve was 357.3 ± 16.73 μg mL−1 hour, volume of distribution was 0.28 ± 0.07 L kg−1 and plasma clearance rate was 0.19 ± 0.009 mL minute−1 kg−1. The plasma concentration of carprofen, administered orally from days 2 to 7, varied from 9.03 ± 1.87 to 11.49 ± 2.15 μg mL−1. Conclusions and clinical relevance Carprofen can be regarded as a long-acting non-steroidal anti-inflammatory drug in pigs.
Language:
English
Keywords:
Carprofen
,
pharmacokinetics
,
swine
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
MF - Faculty of Medicine
VF - Veterinary Faculty
Publication status:
Published
Publication version:
Author Accepted Manuscript
Publication date:
19.01.2021
Year:
2021
Number of pages:
Str. 35-41
Numbering:
Vol. 48, no. 1
PID:
20.500.12556/RUL-124473
UDC:
636.4.09:616-089
ISSN on article:
1467-2987
DOI:
10.1016/j.vaa.2020.09.006
COBISS.SI-ID:
34537987
Publication date in RUL:
25.01.2021
Views:
807
Downloads:
289
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Record is a part of a journal
Title:
Veterinary anaesthesia and analgesia
Shortened title:
Vet. anaesth. analg.
Publisher:
Elsevier
ISSN:
1467-2987
COBISS.SI-ID:
1098874
Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:
25.01.2021
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P4-0053
Name:
Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih
Funder:
ARRS - Slovenian Research Agency
Project number:
P4-0092
Name:
Zdravje živali, okolje in varna hrana
Funder:
ARRS - Slovenian Research Agency
Project number:
P3-0003
Name:
Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev
Funder:
ARRS - Slovenian Research Agency
Project number:
P3-0067
Name:
Farmakologija in farmakogenomika
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