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Vpliv različnih mešanic biopolimerov na kontrolirano sproščanje učinkovin iz zamreženih hidrogelov
ID Kotnik, Jan (Author), ID Ručigaj, Aleš (Mentor) More about this mentor... This link opens in a new window

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Abstract
V okviru te magistrske naloge sem s kombiniranjem hidrogelov, pripravljenih iz različnih biopolimerov, poskušal vplivati na viskoznost, strižni modul in velikost mreže končnih hidrogelov, ki bi se nato lahko uporabili za kontrolirano sproščanje učinkovin. Za doseganje manjše velikosti mreže in boljših mehanskih lastnosti so bili hidrogeli zamreženi z uporabo raztopine kalcijevega klorida kot zamreževala. Z reološkimi meritvami sta bila za posamezne vzorce določena strižni modul in viskoznost. Preko dobljenih strižnih modulov je bila izračunana gostota vozlišč in v nadaljevanju še velikost hidrogelne mreže. Ker načrtovani testi sproščanja niso bili izvedeni, so bili difuzijski koeficienti izbranih modelnih učinkovin določeni zgolj teoretično preko matematičnih modelov.

Language:Slovenian
Keywords:hidrogel, biopolimeri, zamreževanje, reološke meritve, difuzijski koeficient učinkovine
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2020
PID:20.500.12556/RUL-122400 This link opens in a new window
COBISS.SI-ID:42043139 This link opens in a new window
Publication date in RUL:09.12.2020
Views:1403
Downloads:250
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Secondary language

Language:English
Title:Effect of different biopolymer mixtures on the controlled drug release from crosslinked hydrogels
Abstract:
Whit in the scope of this master's thesis I tried to influence the viscosity, shear modulus and mesh size of the final hydrogel, which could then be used for controlled drug release, by combining hydrogels prepared from different biopolymers. To achieve a smaller mesh size and better mechanical properties, the hydrogels were crosslinked using calcium chloride solution as a crosslinker. Rheological measurements were used to determine the shear modulus and viscosity of every individual sample. The cross-link density was calculated via the obtained shear modules, followed by the mesh size of the hydrogel. Since the planned release tests were not performed, the diffusion coefficients of the selected model drug were determined only theoretically via mathematical models.

Keywords:hydrogel, biopolymer, crosslinking, rheological measurements, drug diffusion coefficient

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