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Safety and feasibility of electrochemotherapy of the pancreas in a porcine model
ID Dežman, Rok (Author), ID Čemažar, Maja (Author), ID Serša, Gregor (Author), ID Seliškar, Alenka (Author), ID Erjavec, Vladimira (Author), ID Trotovšek, Blaž (Author), ID Gašljević, Gorana (Author), ID Bošnjak, Maša (Author), ID Lampreht Tratar, Urša (Author), ID Kos, Bor (Author), ID Djokić, Mihajlo (Author), ID Milevoj, Nina (Author), ID Štukelj, Marina (Author), ID Boc, Nina (Author), ID Izlakar, Jani (Author), ID Popović, Peter (Author)

URLURL - Source URL, Visit https://journals.lww.com/pancreasjournal/Fulltext/2020/10000/Safety_and_Feasibility_of_Electrochemotherapy_of.6.aspx This link opens in a new window
Description: Open access

Abstract
Objectives: The use of thermal ablative therapies in the pancreatic tumors is limited because of the risk of the vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) is an ablative therapy with established role in the treatment of cutaneous and liver tumors. This study was designed to evaluate the safety and feasibility of ECT of the pancreas in a porcine survival model. Methods: In the first group, 4 animals underwent computed tomography (CT)%guided percutaneous ECT with bleomycin of the pancreatic tail. In the second group (4 animals), the intraoperative ECTwith bleomycin of pancreatic tail and head was performed. Animals were followed for 7 days and then killed. Clinical parameters, CT imaging, laboratory, and histologic analysis were performed. Results: All pigs survived the ECT procedure and none of them developed clinical signs of acute pancreatitis or related complications. There were no signs of acute pancreatitis or damage to the large vessels present in the follow-up CT scans. No significant change in laboratory parameters was obtained after procedure. Conclusions: This study shows that ECT with bleomycin is feasible and safe in the pancreatic parenchyma. Clinical studies are needed to evaluate the efficacy of ECT in pancreatic cancer.

Language:English
Keywords:electrochemotherapy, electroporation, pancreas, porcine, pancreatic carcinoma
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:VF - Veterinary Faculty
Publication status:Published
Publication version:Version of Record
Year:2020
Number of pages:Str. 1168-1173
Numbering:Vol. 49, no. 9
PID:20.500.12556/RUL-122072 This link opens in a new window
UDC:602.6/.7
ISSN on article:0885-3177
DOI:10.1097/MPA.0000000000001642 This link opens in a new window
COBISS.SI-ID:28129539 This link opens in a new window
Publication date in RUL:19.11.2020
Views:767
Downloads:154
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Record is a part of a journal

Title:Pancreas
Shortened title:Pancreas
Publisher:Raven Press
ISSN:0885-3177
COBISS.SI-ID:512302617 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:19.11.2020

Secondary language

Language:Undetermined
Keywords:elektrokemoterapija, elektroporacija, pankreas, rak trebušne slinavke, prašiči

Projects

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P3-0003
Name:Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev

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