Electroporation - based treatments in small animal veterinary oral and maxillofacial oncology

Nemec, Ana (author), Milevoj, Nina (author), Lampreht Tratar, Urša (author), Serša, Gregor (author), Čemažar, Maja (author), Tozon, Nataša (author)

Electroporation is a method of inducing an increase in permeability of the cell membrane through the application of an electric field and can be used as a delivery method for introducing molecules of interest (e.g., chemotherapeutics or plasmid DNA) into cells. Electroporation-based treatments (i.e., electrochemotherapy, gene electrotransfer, and their combinations) have been shown to be safe and effective in veterinary oncology, but they are currently mostly recommended for the treatment of those solid tumors for which clients have declined surgery and/or radiotherapy. Published data show that electroporation-based treatments are also safe, simple, fast and cost-effective treatment alternatives for selected oral and maxillofacial tumors, especially small squamous cell carcinoma and malignant melanoma tumors not involving the bone in dogs. In these patients, a good local response to treatment is expected to result in increased survival time with good quality of life. Despite emerging evidence of the clinical efficacy of electroporation-based treatments for oral and maxillofacial tumors, further investigation is needed to optimize treatment protocols, improve clinical data reporting and better understand the mechanisms of patients' response to the treatment.

• Language: English
• Keywords: Electroporation, electrochemotherapy (ECT), gene electrotransfer, oral tumors, dog, cats
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: VF - Veterinary Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: art. 575911, str. 1-17
• Numbering: Vol. 7
• PID: 20.500.12556/RUL-122071
• UDC: 636.09:616
• ISSN on article: 2297-1769
• DOI: 10.3389/fvets.2020.575911
• COBISS.SI-ID: 30212611
• Publication date in RUL: 19.11.2020

Record is a part of a journal

• Title: Frontiers in veterinary science
• Shortened title: Front. vet. sci.
• Publisher: Frontiers Media
• ISSN: 2297-1769
• COBISS.SI-ID: 3969402

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 19.11.2020

Secondary language

• Language: Undetermined
• Keywords: Elektroporacija, elektrokemoterapija, genski elektroprenos, ustni tumorji, psi, mačke