Potencial imunoterapij pri zdravljenju raka pljuč

Šelekar, Monika (author), Narat, Mojca (mentor)

Rak pljuč je vodilni razlog smrti po svetu med rakavimi obolenji. Je pogosto pozno odkrita bolezen s slabo prognozo. Možnosti zdravljenja so odvisne od več dejavnikov, vključno z vrsto in stopnjo raka. Bolniki se lahko zdravijo s kemoterapijo, radioterapijo, kirurškimi posegi in ciljno terapijo; pogosto pa zdravljenje poteka s kombinacijo več različnih terapij. Tako kot pri drugih tipih rakavih obolenj pa tudi pri raku pljuč nove možnosti zdravljenja predstavlja imunoterapija. Potencial imunoterapije za zdravljenje se preiskuje v številnih kliničnih študijah, največji uspeh pa so pokazali inhibitorji imunskih kontrolnih točk. Med tem ko se imunoterapija, ki uporablja inhibitorje imunskih kontrolnih točk, že uporablja tudi v praksi, so druge terapije še v različnih stopnjah razvoja. Med temi so največji potencial pokazala antigen specifična cepiva, cepiva na osnovi tumorskih celic ter uporaba adaptivne celične terapije ter citokinov.

• Language: Slovenian
• Keywords: rak pljuč, imunoterapija, cepiva, inhibitorji imunskih kontrolnih točk, od antigena neodvisna imunoterapija
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Publisher: [M. Šelekar]
• Year: 2020
• PID: 20.500.12556/RUL-119804
• UDC: 602.68:606:616-006.6:615.371(043.2)
• COBISS.SI-ID: 32257795
• Publication date in RUL: 11.09.2020

ŠELEKAR, Monika, 2020, Potencial imunoterapij pri zdravljenju raka pljuč [online]. Bachelor’s thesis. M. Šelekar. [Accessed 30 March 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=119804

Secondary language

• Language: English
• Title: The potential of immunotherapies in the treatment of lung cancer

Abstract

Lung cancer is the leading cause of death among cancers worldwide. It is often a late-detected disease with a poor prognosis. Treatment options depend on several factors, including the type and stage of the cancer. Patients can be treated with chemotherapy, radiotherapy, surgery, and targeted therapy; often, however, treatment is done with a combination of several different therapies. As with other types of cancer, immunotherapy is a new treatment option for lung cancer. The potential of immunotherapy for treatment is being investigated in many clinical studies, and the greatest success has been shown by immune checkpoints inhibitors. While immunotherapy using immune checkpoint inhibitors is already being used in practice, other therapies are still in various stages of development. Among these, antigen-specific vaccines, tumor cell-based vaccines, and the use of adaptive cell therapy and cytokines have shown the greatest potential.

• Keywords: lung cancer, immunotherapy, vaccines, immune checkpoint inhibitors, antigen-independent immunotherapy