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Imunski status v času nosečnosti.
ID Koplan, Eva (Author), ID Narat, Mojca (Mentor) More about this mentor... This link opens in a new window

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Abstract
Stanje nosečnosti je z vidika številnih prilagoditev telesa matere zelo kompleksno in zanimivo. Imunski sistem matere mora biti toleranten na delno alogeni plod in mu tako omogočiti nemoteno rast in razvoj brez zavrnitve, istočasno pa mora ščititi mati in plod pred okužbo s patogenimi mikroorganizmi. Do sprememb maternalnega imunskega sistema pride na številnih področjih ob različnih fazah nosečnosti. Ravni hormonov se tekom različnih faz nosečnosti spreminjajo tako, da omogočijo najprej ugnezditev, kasneje rast plodu, po končanem razvoju pa vplivajo na sprožitev poroda. Istočasno pa vplivajo na prilagoditve podskupin imunskega sistema. Pomanjkljiva ali napačna prilagoditev organskih sistemov na nosečnost vodi v resne zaplete v nosečnosti, kot so preeklampsija, ponavljajoči se spontani splavi ali prezgodnji porod, ki pa lahko v najslabšem primeru vodijo v smrt matere ali ploda. V delu so opisane spremembe na nivoju celic NK, makrofagov, celic B in T, citokinov in kemokinov, prilagoditve hormonalnega sistema v nosečnosti in njegov vpliv na druge organske sisteme ter resnost in dovzetnost za okužbe med nosečnostjo.

Language:Slovenian
Keywords:imunologija, imunski status, nosečnost, preeklampsija, hormonalni sistem
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:BF - Biotechnical Faculty
Publisher:[E. Koplan]
Year:2020
PID:20.500.12556/RUL-119710 This link opens in a new window
UDC:601.2:577.27:612.63(043.2)
COBISS.SI-ID:31324675 This link opens in a new window
Publication date in RUL:11.09.2020
Views:1927
Downloads:190
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Secondary language

Language:English
Title:Immune status in pregnancy
Abstract:
The state of pregnancy is very complex and interesting because of many adaptations that transpire in the mother's body. The mother's immune system must be tolerant of the partially allogeneic fetus and thus allow it to grow and develop without rejection, while at the same time protecting the mother and fetus from infection by pathogenic microorganisms. Changes in the maternal immune system occur in many areas during different stages of pregnancy. Hormone levels change during the various stages of pregnancy to allow implantation first, then fetal growth, and after development, affect the initiation of labour. At the same time, they affect the adaptations of other subgroups of the immune system. Deficient or incorrect adaptation of organ systems to pregnancy leads to serious complications in pregnancy, such as preeclampsia, recurrent miscarriages, or premature birth, which can, in the worst case, lead to the death of the mother or fetus. The diploma examines changes in the level of NK cells, macrophages, B and T cells, cytokines and chemokines, adjustments of the hormonal system in pregnancy and its impact on other organ systems, and the severity and susceptibility to infections during pregnancy.

Keywords:immunology, immune status, pregnancy, preeclampsia, endocrine system

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