Open Science Slovenia
New in RUL
The mutual effect of the crosslinker and biopolymer concentration on the desired hydrogel properties
PDF - Presentation file,
URL - Source URL, Visit
Controlled release technology has a great potential in pharmaceutical and medical applications to ensure high efficacy of treatment, reduces the aggressive action of the medicines per patient, decreases the cost of treatment and reduces the side effects of the drug as well. In this research, hydrogels from biopolymers were designed for potential use in the drug release systems. The main objective was the manipulation of alginate and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) - oxidized cellulose nanofibers hydrogels crosslinking density by changing the biopolymer and crosslinker concentrations. Rheological measurements of prepared hydrogels were performed to determine the viscosity as a biomedical applicability factor and for determining shear modulus as a basis for theoretical mesh size calculations. The homogeneity of the hydrogel was confirmed by NMR verifying the validity of the mesh size calculations at the same time. In the last stage, the improved mathematical model was developed taking into account the concentration of crosslinker and the concentration of biopolymer in hydrogel as well. The designed model is the first step for the preparation of hydrogels with specific properties.
drug diffusion coefficient
controlled drug release
1.01 - Original Scientific Article
FKKT - Faculty of Chemistry and Chemical Technology
Version of Record
Number of pages:
ISSN on article:
Publication date in RUL:
Cite this work
Chicago 17th Author-Date
Record is a part of a journal
International journal of biological macromolecules
Int. j. biol. macromol.
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Similar works from RUL:
Similar works from other Slovenian collections: