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The mutual effect of the crosslinker and biopolymer concentration on the desired hydrogel properties
ID Kopač, Tilen (Author), ID Ručigaj, Aleš (Author), ID Krajnc, Matjaž (Author)

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Abstract
Controlled release technology has a great potential in pharmaceutical and medical applications to ensure high efficacy of treatment, reduces the aggressive action of the medicines per patient, decreases the cost of treatment and reduces the side effects of the drug as well. In this research, hydrogels from biopolymers were designed for potential use in the drug release systems. The main objective was the manipulation of alginate and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) - oxidized cellulose nanofibers hydrogels crosslinking density by changing the biopolymer and crosslinker concentrations. Rheological measurements of prepared hydrogels were performed to determine the viscosity as a biomedical applicability factor and for determining shear modulus as a basis for theoretical mesh size calculations. The homogeneity of the hydrogel was confirmed by NMR verifying the validity of the mesh size calculations at the same time. In the last stage, the improved mathematical model was developed taking into account the concentration of crosslinker and the concentration of biopolymer in hydrogel as well. The designed model is the first step for the preparation of hydrogels with specific properties.

Language:English
Keywords:TEMPO nanocellulose, mesh size, drug diffusion coefficient, controlled drug release, mathematical modelling
Work type:Article (dk_c)
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2020
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:Str. 557-569
Numbering:Vol. 159
PID:20.500.12556/RUL-116206 This link opens in a new window
UDC:678
ISSN on article:0141-8130
DOI:10.1016/j.ijbiomac.2020.05.088 This link opens in a new window
COBISS.SI-ID:15760387 This link opens in a new window
Publication date in RUL:22.05.2020
Views:1067
Downloads:265
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Record is a part of a journal

Title:International journal of biological macromolecules
Shortened title:Int. j. biol. macromol.
Publisher:Elsevier
ISSN:0141-8130
COBISS.SI-ID:25637888 This link opens in a new window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:Slovenian
Keywords:biopolimeri, hidrogeli, nanoceluloza, velikost mreže, matematično modeliranje

Projects

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P2-0191
Name:Kemijsko inženirstvo

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