The mutual effect of the crosslinker and biopolymer concentration on the desired hydrogel properties

Kopač, Tilen (author), Ručigaj, Aleš (author), Krajnc, Matjaž (author)

Controlled release technology has a great potential in pharmaceutical and medical applications to ensure high efficacy of treatment, reduces the aggressive action of the medicines per patient, decreases the cost of treatment and reduces the side effects of the drug as well. In this research, hydrogels from biopolymers were designed for potential use in the drug release systems. The main objective was the manipulation of alginate and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) - oxidized cellulose nanofibers hydrogels crosslinking density by changing the biopolymer and crosslinker concentrations. Rheological measurements of prepared hydrogels were performed to determine the viscosity as a biomedical applicability factor and for determining shear modulus as a basis for theoretical mesh size calculations. The homogeneity of the hydrogel was confirmed by NMR verifying the validity of the mesh size calculations at the same time. In the last stage, the improved mathematical model was developed taking into account the concentration of crosslinker and the concentration of biopolymer in hydrogel as well. The designed model is the first step for the preparation of hydrogels with specific properties.

• Language: English
• Keywords: TEMPO nanocellulose, mesh size, drug diffusion coefficient, controlled drug release, mathematical modelling
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: Str. 557-569
• Numbering: Vol. 159
• PID: 20.500.12556/RUL-116206
• UDC: 678
• ISSN on article: 0141-8130
• DOI: 10.1016/j.ijbiomac.2020.05.088
• COBISS.SI-ID: 15760387
• Publication date in RUL: 22.05.2020

Record is a part of a journal

• Title: International journal of biological macromolecules
• Shortened title: Int. j. biol. macromol.
• Publisher: Elsevier
• ISSN: 0141-8130
• COBISS.SI-ID: 25637888

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: biopolimeri, hidrogeli, nanoceluloza, velikost mreže, matematično modeliranje

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P2-0191
• Name: Kemijsko inženirstvo