Uporaba pripravkov za samozdravljenje pri bolnikih z raki prebavil na Kliničnem oddelku za gastroenterologijo Univerzitetnega kliničnega centra Ljubljana

Breška, Andraž (author), Vovk, Tomaž (mentor), Dobravc Verbič, Matej (comentor)

Bolniki z rakom se pogosto poslužujejo pripravkov za samozdravljenje, od zdravil brez recepta do prehranskih dopolnil in drugih pripravkov, kljub pomanjkanju dokazov o njihovi varnosti, kakovosti in učinkovitosti. Namen raziskave je bil opredeliti pripravke za samozdravljenje, ki jih uporabljajo bolniki v gastroonkološki ambulanti Kliničnega oddelka za gastroenterologijo Univerzitetnega kliničnega centra Ljubljana. Zanimalo nas je, koliko bolnikov pripravke uporablja in se o njihovi uporabi posvetuje z zdravstvenim delavcem. Pregledali smo, ali ob njihovem jemanju lahko pride do potencialnih interakcij s sistemsko in podporno terapijo raka. Izvedli smo dvomesečno presečno raziskavo, v katero smo vključili bolnike, ki so prejemali sistemsko terapijo raka v gastroonkološki ambulanti. Podatke o jemanju pripravkov za samozdravljenje smo pridobili s pomočjo vprašalnika, ki so ga bolniki izpolnili ob pregledu. Potencialne interakcije med pripravki in sistemsko ter podporno terapijo raka smo analizirali s pomočjo različnih virov, med drugimi Lexi-Comp's Drug Interactions, Stockley's Herbal Medicines Interactions, monografije Evropske agencije za zdravila in spletne strani Memorial Sloan Kettering Cancer Center. V raziskavo smo vključili 144 bolnikov, zdravljenih v obdobju oktober–november 2018. V tem času je 83 (57,6 %) bolnikov uporabljalo skupno 203 pripravke za samozdravljenje. Spol, starost in izobrazba niso značilno vplivali na uporabo pripravkov med bolniki. Med pripravki je bilo 3,4 % zdravil brez recepta in 59,6 % prehranskih dopolnil. Skupno je bilo največ pripravkov iz konoplje (15,3 %), sicer pa so bolniki najpogosteje uporabljali sok rdeče pese (18,7 % bolnikov), pripravke iz konoplje (18,1 % bolnikov), pripravke z vitamini ali minerali (12,5 % bolnikov), sok aronije (9,0 % bolnikov) in pripravke iz sladkega pelina (6,9 % bolnikov). Bolniki so se glede uporabe posvetovali z zdravstvenim delavcem za 85 (41,9 %) pripravkov. Potencialne interakcije med pripravki za samozdravljenje in sistemsko ali podporno terapijo smo odkrili pri 40 (48,2 %) bolnikov, ki so uporabljali pripravke. Večina podatkov o interakcijah v uporabljenih virih je izhajala iz in vitro raziskav. Za 25 (10,6 %) pripravkov o interakcijah nismo našli ustreznih podatkov.

• Language: Slovenian
• Keywords: pripravki za samozdravljenje, samozdravljenje, raki prebavil, Klinični oddelek za gastroenterologijo, UKC Ljubljana, interakcije zdravil, sistemska terapija, gastroonkološka ambulanta
• Work type: Master's thesis/paper
• Organization: FFA - Faculty of Pharmacy
• Year: 2020
• PID: 20.500.12556/RUL-116196
• Publication date in RUL: 22.05.2020

Secondary language

• Language: English
• Title: The use of complementary medicines in patients with gastrointestinal cancers at the Department of gastroenterology University Medical Centre Ljubljana

Abstract

Cancer patients often resort complementary medicines, from over-the-counter medicines to dietary supplements and other preparations, despite the lack of evidence of their safety, quality and efficacy. The goal of the study was to identify complementary medicines used by the patients treated at the gastro-oncology ambulatory unit at the department of gastroenterology, University medical centre Ljubljana. We wanted to find out how many patients used complementary medicines and whether they consulted a healthcare professional about their use. We looked for potential interactions with systemic and supportive cancer therapy. A two-month cross-sectional study was conducted. We included patients who received systemic cancer therapy at the gastro-oncology ambulatory unit. The data were obtained using a patient questionnaire at the time of examination. Potential interactions between complementary medicines and systemic and supportive cancer therapy were sought using different sources, such as Lexi-Comp's Drug Interactions, Stockley's Herbal Medicines Interactions, European medicines agency monographs and Memorial Sloan Kettering Cancer Center website. 144 patients treated between October and November 2018 were included. During this time, 83 (57.6%) patients used a total of 203 complementary medicines. The use of complementary medicines was not affected by gender, age and education. Among the complementary medicines, 3.4% were over-the-counter medicines and 59.6% were dietary supplements. The most common among complementary medicines were cannabis preparations (15.3%), while most patients were using beetroot juice (18.7% of patients) followed by cannabis preparations (18.1% of patients), vitamins or minerals (12.5 % of patients), aronia juice (9.0% of patients) and wormwood preparations (6.9% of patients). Healthcare professionals were consulted about 85 (41.9%) complementary medicines. Potential interactions between complementary medicines and systemic or supportive therapy were recognized in 40 (48.2%) patients who were using complementary medicines. Most of the data on interactions were from in vitro studies. Relevant data about potential interactions for 25 (10.6%) complementary medicines were not found.

• Keywords: complementary medicines, complementary medicine, gastrointestinal cancers, Department of gastroenterology University Medical Centre Ljubljana, systemic therapy, drug interactions, herb-drug interactions