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Vloga alogenskega trombocitnega gela pri celjenju kroničnih ran spodnje okončine
Semenič, Danijela (Author), Smrke, Dragica maja (Mentor) More about this mentor... This link opens in a new window

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Abstract
Izhodišča: Cilj raziskave je bil primerjati učinek alogenskega trombocitnega gela (aktiviranega po novi metodi) in hidrogela na celjenje kroničnih ran na spodnji okončini. Metode: Študija je bila randomizirana, dvojno slepa in nadzorovana. Obravnavali smo 60 bolnikov (42 moških, 18 žensk, povprečna starost 69,43 let, SD 14,74) s kroničnimi razjedami različnih etiologij. 30 bolnikov je bilo zdravljenih z alogenskim trombocitnim gelom, aktiviranim na nov način (s trombinom 500IU / ml + 40mmol CaCl2 1 ml + aprotininom 100KIU + fibrinogenom 9MG in koagulacijskim faktorjem XIII 6U) in 30 s hidrogelom. Obe skupini sta bili primerljivi glede na čas trajanja rane in njeno velikost. Zdravljenje z nanosom enega izmed gelov se je ponovilo enkrat tedensko, tri tedne zaporedoma, nato pa je bil zadnji pregled opravljen še šest mesecev po prvi uporabi enega izmed gelov. Rezultati: Za analizo neodvisnih vzorcev smo uporabili t-test. Zdravljenje kroničnih ran s trombocitnim gelom je bilo statistično značilno bolj učinkovito v primerjavi z zdravljenjem s hidrogelom (p <0,05). Šest mesecev po aplikaciji trombocitnega gela se je povprečna površina ran v poskusni skupini zmanjšala na 35,01% (SD 53,69) začetne velikosti rane. V kontrolni skupini, zdravljeni s hidrogelom, se je rana zmanjšala na 89,95% (SD 71,82) začetne površine, p = 0,001. Obseg ran je padel na 54,62% (SD 39,85) začetne vrednosti v eksperimentalni skupini, v primerjavi z zmanjšanjem na 91,28% (SD 29,32)zečetnega obsega za kontrolno skupino (p = 0,000). Zaključki: Alogenski trombocitni gel, pripravljen z novo metodo, opisano v tej študiji, predstavlja eno izmed novih možnost zdravljenja kroničnih ran, kadar so druge metode neučinkovite.

Language:English
Keywords:alogenski trombocitni gel, kronične rane, celjenje
Work type:Doctoral dissertation (mb31)
Organization:MF - Faculty of Medicine
Year:2018
Views:380
Downloads:166
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Secondary language

Language:Slovenian
Title:The role of allogenic plateleg gel in healing of chronic wounds of lower extremity
Abstract:
BACKGROUND: The aim of the study was to evaluate the efficacy of allogenic platelet gel (prepared with new method of platelet-rich plasma activation) comparing to hydrogel for treatment of chronic lower leg ulcers. METHODS: The study was prospectively randomised, double blind and placebo controlled. We treated 60 patients (42 males, 18 females, mean age 69.43 years, SD 14.74) with chronic lower leg ulcers of different etiologies. 30 patients were treated with allogenic platelet gel (activated with z trombin 500IU / ml + 40mmol CaCl2 1 ml + aprotinin 100KIU + fibrinogen 9MG and coagulation factor XIII 6U) and 30 with hydrogel. Both groups were comparable for duration of ulcer and its size. Treatment was repeated once a week for three consecutive weeks and then the last examination was done 6 months after the first platelet gel application. RESULTS: For analysing independent samples t-test was used. Healing of chronic wounds with platelet gel was statistically significantly more effective compared to treatment with hydrogel (p<0.05). Six months after platelet gel application, the average wound area in the experimental group decreased to 35.01% (SD 53.69) of the initial wound size. In the control group the wound area decreased to 89.95% (SD 71.82) of initial value, p=0.001. The circumference of the wounds diminished to 54.62% (SD 39.85) of the initial value in the experimental group, compared to 91.28% (SD 29.32)of initial value for the control group (p=0.000). CONCLUSIONS: Allogenic platelet gel prepared by the new method used in this study is a good treatment option for chronic wounds when other methods are ineffective.

Keywords:allogenic plateleg gel, platelets, chronic wounds, healing

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