Introduction: In about 80% of multiple sclerosis patients increased body temperature causes a deterioration of neurological and other motoric symptoms. On the other hand, it is suggested that cooling causes a relief in the symptoms. The aim of the present literature review was to identify if cooling, as a method for decreasing body temperature, relieves the symptoms of multiple sclerosis. Methods: The review was composed of the literature published by 2012. Only the literature giving detailed information on 1) the cooling method applied and 2) the effect of cooling on body temperature was included. Results: Based on the given criteria, eight studies were included in this review. In these, cooling was provided using either cold baths, cooling suits and hat, or cold air exposure. In six studies, a decrease in body core temperature of 0.2 to 2.1 °C was observed. In seven studies, cooling coincided with a relief in the symptoms during, and in one study, also two hours after the cooling. On general, the improvements were observed as improvements in muscle strength and gait, and a decrease in fatigue. Conclusion: It is concluded that cooling represents an efficient method for a temporary relief in the symptoms of multiple sclerosis.