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Analiza parametrov tvorjenja filmske obloge tablete
Janič, Gabriel (Author), Golobič, Iztok (Mentor) More about this mentor... This link opens in a new window, Zupančič, Matevž (Co-mentor)

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Abstract
V magistrskem delu smo obravnavali omočeno površino tabletnega jedra. Naša naloga je bila analizirati vplive disperzije pri različnih pogojih in parametrih, ko ta pride v stik s površino tabletnega jedra. Izvedli smo meritve kota omočenja in hitrosti kapilarnega vleka kapljice na površini tablete. Z nadgrajenim merilnim sistemom, ki je vključeval razpršilno šobo, optični mikroskop in hitro tekočo kamero, smo spremljali dogajanje na površini tablete med procesom tvorjenja filmske obloge. Koti omočenja pri neobloženi tableti z vodo so bili manjši kot pri neobloženi tableti s HPMC, za vodo so bili v območju 30–37° in za HPMC 80–87°. Hitrost kapilarnega vleka se z večanjem temperature povečuje in je pri treh različnih temperaturah 25 ?, 30 ? in 50 ? v območju 1,09–2,71 mm/s. Na osnovi opravljenih meritev smo ocenili, da so za tvorbo filmske obloge dane sestave ugodni naslednji pogoji: atomizacijski tlak 150 kPa, pretok 40 g/min, 10 % disperzija HPMC in temperatura 50 °C.

Language:Slovenian
Keywords:omočena površina, meritve, tabletno jedro, velikost kapljic, hitra kamera, disperzija
Work type:Master's thesis/paper (mb22)
Tipology:2.09 - Master's Thesis
Organization:FS - Faculty of Mechanical Engineering
Year:2020
Publisher:[G. Janič]
Number of pages:XXII, 60 str.
UDC:53.08:615.453.5(043.2)
COBISS.SI-ID:17049371 Link is opened in a new window
Views:35
Downloads:32
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Secondary language

Language:English
Title:Analysis of the tablet film formation parameters
Abstract:
In the master's thesis we discussed the wetted surface of the tablet core. Our task was to analyse the effects of the dispersion under different conditions and parameters, when it comes in contact with the surface of the tablet core. Measurements of the wetting angle and velocity of the capillary traction of the droplet on the tablet surface were performed. With an upgraded measuring system that included a spray gun, an optical microscope and High-Speed camera, we kept track of what was happening on the surface of the tablet during the film coating process. The wetting angles of the uncoated tablet with water, were smaller than those of the uncoated tablet with HPMC. For water, they were in the range of 30–37° and for the HPMC 80–87°. The velocity of the capillary traction increases with increasing temperature and is in the range of 1,09–2,71 mm/s at three different temperatures 25 ␃, 30 ␃ in 50 ␃. Based on the measurements taken, we estimated that for the formation of film coating compositions were given next favourable conditions: atomization pressure 150 kPa, flow 40 g/min, 10 % dispersion and 50 ␃ temperature.

Keywords:wetted surface, measurements, tablet core, droplet size, high speed camera, dispersion

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