Introduction: Buruli ulcer (BU) is an infectious skin disease caused by the bacterium Mycobacterium ulcerans. Disease occurs on the skin in the form of nodules, plaques and lesions that developes into ulcers that affect the extremities of the body. It appears in tropical and subtropical areas of the world, where moisture levels are very high (Africa, South America and some other countries). Incidence is the same in children and adults. In addition to the transfer of infection from the environment, it is also known to transfer from man to man. Treatment is challenging and prolonged and affects the quality of life of the individual. Purpose: The purpose of the thesis is to describe the clinical and epidemiological characteristics of BU, to present health care and its impact on the quality of life. Methods: We have made an overview of domestic and foreign, professional and scientific literature, which extends to the field of treatment and nursing patients with BU. Results: BU is widespread among at least 33 countries with tropical and subtropical areas. Partial data for the year 2017 from 13 countries reported 2206 occurence of infection (most cases originate from Australia and Nigeria). The aim of nursing is to reduce the suffering, disability and socio-economic burden of the patient, his family and the surroundings which also affects the quality of life. Early detection and antibiotic treatment is the cornerstone of the treatment strategy against infection with BU. Experienced healthcare professionals can identify a clinical diagnosis that is reliable and the treatment of infection is extremely rapid. Discussion and conclusion: Treatment of BU is prolonged, conservative and in some cases also surgically. There is a need for greater awareness of Buruli's spread in areas where the incidence is the largest and the rest of the world, as it is not limited to areas with high moisture levels, but also known examples in more developed countries. Despite extensive studies to determine the method of transmission, it is unclear how people acquire disease from the environment. Therefore, prevention is more important. There are still restrictions on treatment for residents in endemic areas that do not lead to medical care due to economic or other causes and consequently have reduced quality of life.