In this master thesis we investigate various models of biological tissue damage resulting from exposure to high temperatures. All models are based on knowing the tissue's temperature. Some of them are directly temperature dependant and some are indirectly dependant. The latter have been upgraded to become directly temperature dependant as well. Different tissues respond differently to an increase in their own temperature, therefore different models are appropriate to describe different tissue. In order to compare performance and suitability, we tested the models on cell and tissue viability measurements and critical temperature measurements as a function of exposure time (Arrhenius curve). Thus, we calculated the tissue parameters for all the models used and compared them with those already published. We also wanted to know if any of the models were versatile. VHS model followed by enzyme denaturation model were best suited for describing the Arrhenius curves and heat-induced clonogenic cell death model for the overall description of all measurements. Each model described its own measurements very well. In only one case where the model was made on the basis of their own measurements, it turned out that another model described these same measurements even better.