izpis_h1_title_alt

Sinteza fluoroforov s 4-feniletinil-fenilaminskim skeletom
ID Žnideršič, Nika (Author), ID Gazvoda, Martin (Mentor) More about this mentor... This link opens in a new window

.pdfPDF - Presentation file, Download (1,75 MB)
MD5: E7543665B0BB011BC151D4520E4790E0

Abstract
Cilj diplomske naloge je bila sinteza novih fluoroforov s 4-feniletinil-fenilaminskim skeletom, ki bi bili na podlagi svojih optičnih in vezavnih lastnosti primerni za detekcijo proteina tau in vitro kot tudi in vivo. Sinteza 4-(4-((4-(etil(2-fluoroetil)amino)fenil)etinil)fenil)-6-metil-2-okso-2H-piran-3-karbonitril je vključevala reakcijo Claisenove kondenzacije, pripajanje po Sonagashiri in fluoriranje. Uspešno je bil sintetiziran diketon 1-(4-((4-(etil(2-hidroksietil)amino)fenil)etinil)fenil)butan-1,3-dion, ki lahko služi kot izhodna spojina za pripravo želene končne spojine.

Language:Slovenian
Keywords:molekulska sonda, organska sinteza, reakcija pripajanja, fluoriranje
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2019
PID:20.500.12556/RUL-109940 This link opens in a new window
COBISS.SI-ID:1538425283 This link opens in a new window
Publication date in RUL:10.09.2019
Views:1188
Downloads:291
Metadata:XML RDF-CHPDL DC-XML DC-RDF
:
Copy citation
Share:Bookmark and Share

Secondary language

Language:English
Title:Synthesis of fluorofores with 4-phenylethynyl-phenylamine skeleton
Abstract:
The goal of this thesis was to synthesize new fluorophores with 4-phenylethynyl-phenylamine scaffold that would be suitable for detection of tau protein in vitro as well as in vivo, based on their optical and binding properties. Synthesis of 4-(4-((4-(ethyl(2-fluoroethyl)amino)fenyl)ethynyl)fenyl)-6-methyl-2-oxo-2H-pyran-3-carbonitrile included Claisen condensation, Sonagashira coupling and fluorination reaction. Diketone 1-(4-((4(ethyl(2-hydroxyethyl)amino)¬phenyl)ethynyl)¬phenyl)¬butane-1,3-dione was successfully synthesized and can serve as a starting compound for the synthesis of the desired compound.

Keywords:molecular probe, organic synthesis, coupling reaction, fluorination reaction

Similar documents

Similar works from RUL:
Similar works from other Slovenian collections:

Back