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Sinteza fluoroforov s 4-aminobifenilnim skeletom
ID Marsel, Aleš (Author), ID Gazvoda, Martin (Mentor) More about this mentor... This link opens in a new window

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Abstract
Na podlagi molekulskih sond, ki kažejo ugodne optične in vezavne lastnosti na protein tau, smo zasnovali in z uporabo klasičnih in modernih sinteznih metod pripravili nove molekule z različnimi elektron-akceptorskimi skupinami. Prost tok elektronov od elektron-donorske do elektron-akceptorske skupine v novih spojinah obljublja ugodne optične lastnosti za fluorescenčno mikroskopijo, hkrati pa stranska veriga aminske skupine omogoča vključitev radioaktivnega fluora-18 in s tem uporabo pri slikanju s pozitronsko emisijsko tomografijo.

Language:Slovenian
Keywords:Sinteza, fluorofori, 4-aminobifenil
Work type:Bachelor thesis/paper (mb11)
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2019
COBISS.SI-ID:1538326723 This link opens in a new window
Publication date in RUL:06.09.2019
Views:524
Downloads:162
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Secondary language

Language:English
Title:Synthesis of fluorophores with a 4-aminobiphenyl skeleton
Abstract:
Based on previous research on molecular probes with favorable optical and binding properties towards protein tau, we designed and using classic and modern synthetic methods prepared new molecules with different electron-accepting groups. Free flow of electrons from electron-donating to electron-accepting groups in new compounds promises good optical properties for fluorescence microscopy, while side chain of the amine group offers an option to add radioactive fluorine-18, for use in positron emission tomography imaging.

Keywords:Synthesis, flurophores, 4-aminobiphenyl

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