Sinteza fluoroforov s 4-aminobifenilnim skeletom

Marsel, Aleš (author), Gazvoda, Martin (mentor)

Na podlagi molekulskih sond, ki kažejo ugodne optične in vezavne lastnosti na protein tau, smo zasnovali in z uporabo klasičnih in modernih sinteznih metod pripravili nove molekule z različnimi elektron-akceptorskimi skupinami. Prost tok elektronov od elektron-donorske do elektron-akceptorske skupine v novih spojinah obljublja ugodne optične lastnosti za fluorescenčno mikroskopijo, hkrati pa stranska veriga aminske skupine omogoča vključitev radioaktivnega fluora-18 in s tem uporabo pri slikanju s pozitronsko emisijsko tomografijo.

• Language: Slovenian
• Keywords: Sinteza, fluorofori, 4-aminobifenil
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2019
• PID: 20.500.12556/RUL-109668
• COBISS.SI-ID: 1538326723
• Publication date in RUL: 06.09.2019

Secondary language

• Language: English
• Title: Synthesis of fluorophores with a 4-aminobiphenyl skeleton

Abstract

Based on previous research on molecular probes with favorable optical and binding properties towards protein tau, we designed and using classic and modern synthetic methods prepared new molecules with different electron-accepting groups. Free flow of electrons from electron-donating to electron-accepting groups in new compounds promises good optical properties for fluorescence microscopy, while side chain of the amine group offers an option to add radioactive fluorine-18, for use in positron emission tomography imaging.

• Keywords: Synthesis, flurophores, 4-aminobiphenyl