Plazemska oksidacija NiTi zlitine za uporabo v medicini

Filipič, Maša (author), Kovač, Janez (mentor), Junkar, Ita (comentor)

V diplomskem delu smo izvedli plazemsko oksidacijo Ni-Ti zlitine z namenom tvorbe zaščitne oksidne plasti TiO2 na Ni-Ti kovinski podlagi. S tem smo povečali korozijsko odpornost in biokompatibilnost zlitine, kar je zelo pomembno za uporabo žilnih opornic iz Ni-Ti zlitine v medicini. Plazemska obdelava vzorcev je potekala v vodikovi in kisikovi plazmi pri tlaku 30 Pa z različnimi časi obdelave od 5 do 20 s. Primerjalni vzorec je bila neobdelana Ni-Ti zlitina. Vzorce smo analizirali z metodami rentgenske fotoelektronske spektroskopije (XPS), masne spektrometrije sekundarnih ionov (ToF-SIMS) in vrstične elektronske mikroskopije (SEM), da bi ugotovili kemično sestavo površine in oksidnih plasti ter morfologijo in mikrostrukturo oksidnih plasti. Za določanje biološkega odziva smo opravili in vitro biološke teste s polno človeško krvjo, da bi ugotovili, ali se trombociti na površino vežejo in aktivirajo. Pokazali smo, da se s časom obdelave v plinski plazmi povečuje debelina oksidne plasti, ki je iz TiO2 in ne vsebuje niklja. Barva vzorcev po plazemski obdelavi je odvisna od debeline oksidne plasti. Dobljena zaščitna oksidna plast zmanjša adhezijo in aktivacijo trombocitov iz polne krvi na Ni-Ti zlitini.

• Language: Slovenian
• Keywords: Ni-Ti zlitina, plazemska oksidacija, XPS, ToF-SIMS, žilne opornice, biokompatibilnost
• Work type: Bachelor thesis/paper
• Organization: NTF - Faculty of Natural Sciences and Engineering
• Year: 2019
• PID: 20.500.12556/RUL-107715
• COBISS.SI-ID: 1814623
• Publication date in RUL: 16.05.2019

FILIPIČ, Maša, 2019, Plazemska oksidacija NiTi zlitine za uporabo v medicini [online]. Bachelor’s thesis. [Accessed 27 March 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=107715

Secondary language

• Language: English
• Title: Plasma oxidation of NiTi alloy for medical application

Abstract

The main aim of the research off my thesis was to form a protective oxide layer TiO2 on the Ni-Ti metal surface by carrying out the plasma oxidation of the Ni-Ti alloy. With the plasma treatment the corrosion resistance and the biocompatibility of the Ni-Ti alloy were increased, which are very important properties for medical applications. The plasma treatment was performed at pressure of 30 Pa in hydrogen and oxygen plasma with a different treatment times ranging from 5 s to 20 s. The untreated sample of Ni-Ti alloy was taken for comparison. All samples were analyzed by the X-Ray Photoelectron Spectroscopy (XPS), Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Scanning Electron Microscopy (SEM) to determine the chemical composition of the surface and the oxide layers and the morphology and microstructure of the oxide layers. In order to asses biocompatibility of samples in vitro biological tests with a whole blood were performed. We have shown that TiO2 oxide rich layer is formed with plasma, which does not contain Ni. The thickness of the TiO2 oxide layer increases by plasma treatment time. Changes of the colour of samples reflect the change of the oxide layer thickness. It was shown that the protective oxide layer of TiO2 on Ni-Ti alloy reduces adhesion and activation of platlets from whole blood.

• Keywords: Ni-Ti alloy, plasma oxidation, XPS, ToF-SIMS, stents, biocompatibility