Introduction: The World Health Organization estimates that every fourth couple in developing countries is facing infertility. Fertilization with biomedical assistance has significantly contributed as a resolution to the problem of infertility, despite achieving a successful pregnancy, the battle with psychological aspects of such diagnosis continues. Purpose: The purpose of the diploma work is to determine whether the experience of pregnancy and parenting in pregnant women and couples who were previously treated for infertility differs, from the experience of pregnant women and couples who have become pregnant spontaneously. We wanted to find out whether pregnancy after infertility treatment is more likely to cause stress, anxiety, fear of birth, poor self-esteem and less attachment to the child. Methods: We used a descriptive method of work, a systematic review of literature was made. We searched for sources in the following databases: CINAHL, MEDLINE, ScienceDirect and SocINDEX. With this method and checking the reference lists we identified 1044 units, of which 19 articles were included in the final analysis. GRADE scale was used to assess the quality of analyzed articles. Results: Despite many studies, evidence of experiencing anxiety and stress during pregnancy is unconvincing for a firm conclusion. It is important to note that women after fertilization with biomedical assistance are often less anxious about child's health than those after spontaneous pregnancy. What may indicate that women have the wrong impression of the state of the embryo, since fertilization with biomedical assistance does not necessarily mean a child without health problems. The quality of couples' life after fertilization with biomedical assistance is much lower in the assessment of social activity, sexuality and physical well-being, which can be linked to the fact that such pregnancy is associated with a greater risk of complications during pregnancy and childbirth. Discussion and conclusion: In general, it seems that women who are pregnant after fertilization with biomedical assistance have a higher level of specific, pregnant-related anxiety and poor quality of life in some respects. At the same time, they cope with pregnancy and it’s challenges more positive than women who become pregnant spontaneously. A long history of unsuccessful treatment, an absent partner, a life that is completely focused on the child, and the absence of sexual satisfaction can be indicators of upcoming problems and negative feelings. Genuine understanding and exchange of information both by health professionals and couples after fertilization with biomedical assistance provides a sincere relationship that is the basis for solving challenges and problems when they occur. Only in this way can we create a positive and "fertile" atmosphere that enables the couples to make the transition from infertility to family life-which they were expecting so hard-as easy and positive as it can be.