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Vpliv okoljskih in genetskih dejavnikov na nastanek debelosti in metabolnega sindroma : magistrsko delo
ID Šoštarič, Anja (Author), ID Milisav, Irina (Mentor) More about this mentor... This link opens in a new window

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Abstract
Uvod: Metabolni sindrom (MeS) in z njim povezane bolezni so globalni zdravstveni problem. Identifikacija enostavnih metod za odkrivanje zdravih posameznikov z zgodnjimi kazalniki metabolnih sprememb, ki so izhodišče za razvoj MeS, bi omogočila pravočasno uvedbo preventivnih sprememb v načinu življenja. Namen: Namen magistrskega dela je oceniti in opredeliti načine, kako identificirati osebe s povečano verjetnostjo za razvoj MeS, še pred izražanjem kriterijev za diagnozo le-tega. Metode dela: Zdravi preiskovanci so bili ocenjeni z indikatorji metabolnih sprememb, določenih na osnovi antropometričnih, biokemijskih in farmakogenskih meritev ter vprašalnika. Preiskovanci, ki so izkazovali vsaj eno merilo priznanih definicij mednarodnih zdravstvenih organizacij za diagnozo MeS, so bili uvrščeni v skupino z večjo obremenitvijo MeS (B-MeS). Rezultati: Analiza meritev z nekaj dodatnimi vprašanji je opredelila skupino zdravih odraslih preiskovancev z višjim tveganjem za razvoj MeS (B-MeS). Razprava in sklep: Izvlečki meritev, ki smo jih analizirali, nakazujejo potencial za implementacijo v preventivne zdravstvene preglede. Na podlagi teh parametrov bi identificirali posameznike, ki imajo tvegan življenjski stil in navade, ki privedejo do zgodnjega razvoja MeS. Posledično bi z enostavnimi spremembami in interveniranjem v načinu prehranjevanja in telesne aktivnosti preprečili klinično sliko MeS pri teh posameznikih, s tem pa zmanjšali stroške zdravljenja in obseg prilagojenih življenjskih let zaradi invalidnosti v celotni populaciji.

Language:Slovenian
Keywords:metabolni sindrom, debelost, mladi odrasli, antropometrične meritve, življenjski slog, dieta, prehrana, gibanje, genetski dejavniki, socialni dejavniki
Work type:Master's thesis/paper (mb22)
Organization:ZF - University College of Health Studies
Year:2019
COBISS.SI-ID:5573483 This link opens in a new window
Publication date in RUL:27.01.2019
Views:1084
Downloads:459
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Secondary language

Language:English
Title:Environmental and genetic influences on obesity and metabolic syndrome development : masterʹs thesis
Abstract:
Introduction: An important global health challenge is metabolic syndrome with associated diseases. A priority for addressing this diseases is identification of simple and cost-effective methods for assessment of healthy individuals with early metabolic modifications leading to metabolic syndrome that would enable a timely introduction of preventive lifestyle modifications. Purpose: To assess whether individuals with an increased likelihood of metabolic syndrome formation could be identified in the healthy population, before meeting the three criteria on which the metabolic syndrome (MeS) diagnosis is established. Methods: Young healthy adults, that manifested at least one fulfilled criterion for the diagnosis of metabolic syndrome, were assigned to a group with a higher metabolic syndrome burden (B-MeS). Results: A sub-group of young healthy adults with a higher B-MeS was identified, based on the analyses of anthropometric and biochemical measurements and a follow-up questionnaire. This sub-group may also have an increased risk for developing MeS. Discussion and conclusion: Measurements and analyses used in this study can be scaled-up to perform periodic check-ups of a healthy population. Lifestyle factors have a big influence on development or improvement of MeS. Therefore, a timely diagnosis for B-MeS would enable an early intervention for lifestyle modifications in a still healthy population, saving costs and reducing disability adjusted life years.

Keywords:metabolic syndrome, obesity, young adults, anthropometry, lifestyle, diet, nutrition, exercise, genetic factors, social factors

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