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Numerično načrtovanje tuljave v obliki številke osem za namen elektroporacije z izmeničnim magnetnim poljem
OŠLAJ, MOJCA (Author), Kranjc, Matej (Mentor) More about this mentor... This link opens in a new window

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Abstract
S klasično elektroporacijo danes dosegamo dobre rezultate na različnih področjih uporabe, od elektrokemoterapije, genskega transferja do pasterizacije hrane in elektrozlivanja. Zaradi izpostavitve celice električnemu polju se namreč v celični membrani začnejo dogajati spremembe, ki pod določenimi pogoji omogočajo prehod ionov in molekul, katerim je ob normalnih okoliščinah vstop onemogočen. Kot alternativa elektroporacije z pulznim električnim poljem pa se v zadnjem času poraja ideja o permeabilizaciji celične membrane z uporabo izmeničnega magnetnega polja. Ta metoda še ni dokončno raziskana, vendar je zelo uporabna predvsem v primerih, kjer je dostop z navadnimi elektrodami onemogočen ali prenevaren. V svoji magistrski nalogi sem med izbranimi omejitvami s pomočjo numeričnega modeliranja poiskala najboljšo tuljavo v obliki številke osem (ang.: figure-8 coil), s katero bi lahko ustvarili inducirano električno polje. Tuljava v obliki osmice nam ponuja boljšo osredotočenost področja stimulacije, sama globina dosega pa je še vedno vprašljiva. Težko se je odločiti, katera tuljava je na splošno najboljša, saj so se nekatere omogočale vzpostavitev večje jakosti elektičnega polja, druge pri gostoti magnetnega pretoka in tretje pri večji globini dosega. S predlagano tuljavo dosežemo v sredini tuljave električno poljsko jakost 101,76 V/m in gostoto magnetnega polja 855,49 mT, s čimer smo sicer zadovoljni, vendar bi se dalo primernejšimi vhodnimi parametri rezultate še izboljšati.

Language:Slovenian
Keywords:elektroporacija, magnetno polje, inducirano električno polje, numerično modeliranje, tuljava v obliki številke osem
Work type:Master's thesis/paper (mb22)
Organization:FE - Faculty of Electrical Engineering
Year:2018
Views:591
Downloads:299
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Secondary language

Language:English
Title:Numerical modelling of figure-8 coil in electroporation induced by time-varying magnetic field
Abstract:
Nowadays we achieve good results with classical electroporation in various fields of use from electrochemotherapy, gene transfer to pasteurization of food and electrofusion. Due to exposure of the cell to the electric field, changes in the cell membrane begin to occur. These changes, under certain conditions, allow transition to ions and molecules, which is in normal circumstances prevented. As an alternative to electroporation with a pulsed electric field, the idea of permeabilizing the cell membrane using an alternating magnetic field has recently been raised. This method has not yet been fully explored, but it is very useful especially in cases where access to ordinary electrodes is disabled or too dangerous. In my master's thesis, I found the best figure-8 coil through numerical modelling among the selected constrains, with which we could create an induced electric field. Figure-8 coil offers us a better localization of stimulation area, but the depth of reach remains questionable. It is difficult to decide which coil is generally the best, since some have proved to be better at the strength of the electric field, the other at the density of magnetic flux and third at a greater depth of reach. In the middle of the coil the electric field strength of 101.76 V/m and a magnetic field density of 855.49 mT is reached. We are satisfied with those results, but with better input parameters, the results could be further improved.

Keywords:electroporation, magnetic field, induced electric field, numerical modelling, figure-8 coil

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