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Lipidni vesikli v valjasti ograditvi
ID Lapajne, Jure (Author), ID Ziherl, Primož (Mentor) More about this mentor... This link opens in a new window

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Abstract
V delu predstavimo model vesikla v cilindrični ograditvi. Model temelji na vesiklih, sestavljenih iz geometrijsko preprostih oblik, za katere lahko analitično izračunamo površino, reducirano razliko površin monoslojev in upogibno energijo. Ideje za mo- delske oblike smo dobili ob pregledovanju slik mitohondrija pod elektronskim mikroskopom in elektronskih tomogramov. Vsaki obliki pripišemo lokalno in nelokalno upogibno energijo, upoštevamo pa tudi medmembransko interakcijo, ki je sorazmerna medmembranski kontaktni površini. Na koncu predstavimo fazne diagrame ter jih povežemo s prehodi med ortodoksnim in kondenziranim stanjem mitohondrija.

Language:Slovenian
Keywords:mitohondrij, ograjeni vesikel, upogibna energija, medmembranska interakcija, cilindrična ograditev, polnilno razmerje
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FMF - Faculty of Mathematics and Physics
Year:2018
PID:20.500.12556/RUL-102855 This link opens in a new window
COBISS.SI-ID:3258724 This link opens in a new window
Publication date in RUL:09.09.2018
Views:1626
Downloads:227
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Secondary language

Language:English
Title:Lipid vesicles in cylindrical confinement
Abstract:
In this thesis we present a simple model of a vesicle confined in a cylindrical cavity. The model is based on vesicles assembled from simple geometrical shapes for which analytical expressions for surface, area difference of monolayers and bending energy are easily calculated. Shapes used in the presented model are inspired by electron micrographs and electron tomograms of mitochondria. For each shape we calculate the local and non-local bending energy, and we also include the intermembrane interaction, which is proportional to intermembrane contact area. We present the phase diagrams and connect them with the transition between the orthodox and the condensed state in mitochondria.

Keywords:mitochondrion, confined vesicle, bending energy, intermembrane interaction, cylindrical confinement, packing fraction

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