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Delovanje probiotikov proti virusom
Pristovšek, Neja (Author), Bogovič Matijašić, Bojana (Mentor) More about this mentor... This link opens in a new window

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Abstract
Respiratorne, gastrointestinalne, spolno prenosljive in druge infekcije, ki jih povzročajo virusi, so zelo razširjene, soočamo pa se tudi z naraščajočo odpornostjo proti protivirusnim zdravilom. V svetu narašča povpraševanje po novih nekonvencionalnih protivirusnih zdravilih za obvladovanje oziroma lajšanje virusnih infekcij, ki predstavljajo alternativo za tista, ki so v uporabi danes. Med njimi omenjajo tudi probiotike. Medtem ko je učinkovanje probiotikov na bakterijske infekcije relativno dobro pojasnjeno (tekmovanje za hranila, neposredna inhibicija, vpliv na imunski sistem), pa so delovanje probiotikov proti virusom začeli raziskovati šele v zadnjem času. Pozitivne učinke probiotikov pri virusnih infekcijah je mogoče pripisati predvsem izboljšanju črevesne homeostaze in barierne funkcije črevesa. Posamezni probiotični sevi so sposobni vplivati na mukozni ali sistemski imunski odziv. Vplivajo lahko na signalne poti, tako da izboljšajo imunski odgovor na viruse. Specifični sevi rodov Lactobacillus in Bifidobacterium lahko zavirajo replikacijo virusa influence. L. rhamnosus GG zmanjša možnost okužbe zgornjega dihalnega trakta. V primeru akutnega gastroenteritisa seve L. rhamnosus GG, L. reuteri DSM 17938, S. boulardii CNCM I-745 uporabljamo za zdravljenje driske. Pri bolnikih, okuženih z virusom HIV, pa so izboljšanje pod vplivom probiotikov (L. rhamnosus, L. casei) pripisali izboljšanjemu zdravljenju sluznice preko modulacije mikrobiote, zmanjšanju vnetja in izboljšanju fizične in imunske integritete črevesne mukoze. Prav tako se je protivirusno delovanje rodov Lactobacillus in Bifidobacterium izkazalo kot učinkovito pri virusnih spolnih okužbah.

Language:Slovenian
Keywords:probiotiki, virusi, HIV, mikrobiota, virusne respiratorne okužbe, virusni gastroenteritis, HPV, virus herpes simpleks, kokseki virus
Work type:Bachelor thesis/paper (mb11)
Tipology:2.11 - Undergraduate Thesis
Organization:BF - Biotechnical Faculty
Year:2018
Publisher:[N. Pristovšek]
UDC:615.281.8+615.372:579.8
COBISS.SI-ID:4936312 Link is opened in a new window
Views:683
Downloads:348
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Secondary language

Language:English
Title:Antiviral activity of probiotics
Abstract:
Respiratory, gastrointestinal, sexually transmitted and other viral infections are very common and resistance to antiviral drugs is growing. The interest for new unconventional antiviral medications for control of virus diseases and symptom relief, as an alternative to those which are in use nowadays is growing worldwide. Among them probiotics are also mentioned. While the effect of probiotics on bacterial infections is relatively well understood (competition for nutrients, direct inhibition and effect on immune system), the research of antiviral activity of probiotics has only begun in recent times. The positive effects of probiotics against viral infections can be attributed primarily to the improvement of intestinal homeostasis and the gut barrier function. Specific probiotic strains are able to affect the mucosal or systemic immune response. They can modulate signalling pathways by improving immune response to virus. Specific strains of the genera Lactobacillus and Bifidobacterium can inhibit replication of influenza virus. L. rhamnosus GG decreases the possibility of the upper respiratory tract infections. In the case of acute gastroenteritis, L. rhamnosus GG, L. reuteri DSM 17938, S. boulardii CNCM I-745 strains can be used for the treatment of diarrhea. The improvements in patients infected with HIV, under the influence of probiotics (L. rhamnosus, L. casei) were assigned to modulation of the microbiota, reduction of the inflammation and improvement of physical and immune integrity of gut mucosa. Lactobacillus and Bifidobacterium also proved to be effective in viral sexually transmitted diseases.

Keywords:probiotics, viruses, HIV, microbiota, viral respiratory infections, viral gastroenteritis, HPV, herpes simplex virus, coxsackievirus

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