Nutrigenomika in nutrigenetika.

Zevnik, Kaja (author), Jamnik, Polona (mentor)

V diplomskem delu sta predstavljeni nutrigenomika in nutrigenetika. Nutrigenetika preučuje, kako lahko različice v genetskem zapisu med posamezniki spremenijo njihov fiziološki odziv na hrano, nutrigenomika pa po drugi strani preučuje neposreden in posreden vpliv komponent hrane na genom, transkriptom, proteom in metabolom, ter s tem na regulacijo izražanja genov in stabilnost DNA. Komponente hrane imajo lahko vlogo ligandov za transkripcijske faktorje ter so vključene v številne metabolne poti, s tem pa spreminjajo koncentracije substratov in intermediatov vključenih v regulacijo izražanja genov. Poleg tega lahko vplivajo na signalne poti, na posttranslacijske modifikacije proteinov, lahko pa imajo tudi vlogo koencimov ali ostalih encimskih kofaktorjev.

• Language: Slovenian
• Keywords: hrana, nutrigenomika, nutrigenetika, prehranska genomika
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Publisher: [K. Zevnik]
• Year: 2018
• PID: 20.500.12556/RUL-101838
• UDC: 60:612.39:575.113(043.2)
• COBISS.SI-ID: 9006457
• Publication date in RUL: 08.07.2018

ZEVNIK, Kaja, 2018, Nutrigenomika in nutrigenetika. [online]. Bachelor’s thesis. K. Zevnik. [Accessed 18 May 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=101838

Secondary language

• Language: English
• Title: Nutrigenomics and nutrigenetics

Abstract

In the thesis nutrigenomics and nutrigenetics are described. Nutrigenetics studies how genetic variants among individuals can change their physiological response to food, while nutrigenomics, on the other hand, studies the direct and indirect influence of food components on genome, transcriptome, proteome, and metabolome, thereby on the regulation of gene expression and on the stability of DNA. Food components can act as ligands for transcription factors and are included in many metabolic pathways, which causes changes in the concentrations of substrates and intermediates, involved in the regulation of gene expression. They can also affect signal pathways, posttranslational modifications of proteins and may have a role of coenzymes or other enzyme cofactors.

• Keywords: food, nutrigenomics, nutrigenetics, nutritional genomics