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Regulacija pluripotentnosti v matičnih celicah.
ID Bole, Martin (Author), ID Ogorevc, Jernej (Mentor) More about this mentor... This link opens in a new window

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Abstract
Z izrazom pluripotentne matične celice označujemo nediferencirane celice, ki se lahko razvijejo v vse tri tipe zarodnih tkiv (endoderm, ektoderm in mezoderm), ne pa tudi v ekstra embrionalna tkiva. To pomeni sposobnost razvoja v več kot 200 različnih tipov celic. Njihova glavna značilnost je zmožnost neskončnega samoobnavljanja in vitro in plastičnost, saj preko celičnih delitev ne izgubijo potenciala za diferenciacijo v različne tipe tkiv. In vivo je pluripotentno stanje embrionalnih celic in je le kratko prehodno stanje v razvoju zarodka, ki nato vodi v nadaljno diferenciacijo celic in embrionalnih tkiv. Regulacija pluripotentnosti poteka na nivoju epigenetskih modifikacij, inhibicije z miRNA, različnih transkripcijskih faktorjev in majhnih molekul.

Language:Slovenian
Keywords:matične celice, stanja pluripotence, epigenetika, transkripcijski faktorji, hranilna podlaga
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:BF - Biotechnical Faculty
Publisher:[M. Bole]
Year:2018
PID:20.500.12556/RUL-101459 This link opens in a new window
UDC:602.9:611.018:591.81(043.2)
COBISS.SI-ID:8983673 This link opens in a new window
Publication date in RUL:06.06.2018
Views:1436
Downloads:355
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Secondary language

Language:English
Title:Regulation of pluripotency in stem cells
Abstract:
Pluripotent stem cells are undifferentiated cells, which can then evolve into all three germ layers (endoderm, ectoderm and mesoderm) but not to extraembryonic tissue. This means that they can differentiate into more than 200 types of cells. Their main characteristics is the ability to self-renew in vitro and their plasticity, as they do not lose the ability to differentiate even after multiple cell divisions. In vivo, pluripotency is a short transitional phase of the embryo, that then leads to further differentiation of cells and tissues. The cells regulate their pluripotency trough epigenetic modifications, miRNA interference, various transcriptional factors and small molecules.

Keywords:stem cells, pluripotency states, epigenetics, transcriptional factors, feeder layer

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