Introduction: Intubation with rapid sequence induction is a technique designed to facilitate endotracheal intubation in patients with a high risk of aspiration. Aspiration is associated with the onset of complications during anaesthetic procedures and is an important cause of mortality and morbidity in anaesthesia. The nurse must often be familiar with novelties in order to provide the most optimal techniques for patient’s safety. Purpose: The purpose of this thesis is to present the intubation with rapid sequence induction, the success of intubation with rapid sequence induction, the advantages and disadvantages of the cricoid pressure, to present the role of a nurse in performing intubation with rapid sequence induction in and out of hospital environment, and to confirm the three hypotheses through a meta-syntheses of clinical studies: intubation with rapid sequence induction is compared to intubation without premedication more effective; the nurse is competent to assist in the implementation of intubation with rapid sequence induction; cricoid pressure prevents aspiration od gastric contents. Methods: A descriptive method is used. We have performed a literature review on the topic discussed and meta-syntheses of scientific studies. Literature search methods included COBISS.si portal and different databases, namely Cohrane, Cinahl with full text, Wiley, NIH (National Institutes of Health), Medline, and PubMed. Results: Meta-synthesis of clinical studies was performed using a four-level scale by Eccles and Mason. The highest valued arguments are marked as level I, whilst the lowest are marked with IV. Only one hypothesis was confirmed, and that was that intubation with rapid sequence induction, compared with intubation without premedication, is more effective. The hypothesis that nurses are capable to assist in the implementation of intubation with rapid sequence induction was not proven, as the research has shown that in spite of the fact that nurses work in emergency departments, in procedures where they help, they do not perform the intubation often enough and because of that they had not shown adequate level of competence. The hypothesis that cricoid pressure prevents aspiration, research and opinions are divergent, so we could not confirm it. Discussion and conclusion: Intubation with rapid sequence induction is an effective method of intubation both in prehospital and hospital care, which aims to prevent regulgitation and aspiration. Opinions on the use of cricoid pressure are still opposite, as there are more and more evidence that call into question the efficacy and safety of cricoid pressure, so that the application itself lies in the hands of individual anaesthetist. The nurse can cooperate and assist in intubation with rapid sequence induction if she has additional simulation training as the knowledge and competence of nurses is influenced by the frequency of performing certain intervention. Intubation is a critical procedure that is not performed very often, which affects the independence and self-confidence of a nurse.
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