1. Structural isomerism and enhanced lipophilicity of pyrithione ligands of organoruthenium(II) complexes increase inhibition on AChE and BuChEJerneja Kladnik, Samuel Ristovski, Jakob Kljun, Andrea Defant, Ines Mancini, Kristina Sepčić, Iztok Turel, 2020, original scientific article Keywords: Alzheimer’s disease, acetylcholinesterase, butyrylcholinesterase, cholinesterase inhibitor, molecular docking, organoruthenium(II) complexes, pyrithione derivatives
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2. Fine tuning of cholinesterase and glutathione-S-transferase activities by organoruthenium(II) complexesTomaž Trobec, Kristina Sepčić, Monika C. Žužek, Jerneja Kladnik, Nina Podjed, Catarina Cardoso Páscoa, Iztok Turel, Robert Frangež, 2021, original scientific article Keywords: cholinesterase, enzyme inhibition, glutathione S-transferase, organoruthenium complex, pyrithione, β-diketone, carbonyl, glutathione transferase
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3. New insights into the effects of organometallic ruthenium complexes on nicotinic acetylcholine receptorsTomaž Trobec, Nicolas Lamassiaude, Evelyne Benoit, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Iztok Turel, Rómulo Aráoz, Robert Frangež, 2024, original scientific article Keywords: organometallic ruthenium complexes, nicotinic acetylcholine receptors, nicotinic antagonists, electrophysiology, two-electrode voltage-clamp technique
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4. Structural and functional characterization of an organometallic ruthenium complex as a potential myorelaxant drugTomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Jakob Kljun, Iztok Turel, Evelyne Benoit, Robert Frangež, 2020, original scientific article Keywords: organoruthenium nitrophenanthroline complex, acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, mouse neuromuscular system, ruthenium, muscle relaxation, physiology, glutathione transferase
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5. Novel organoruthenium(II) complex C1 selectively inhibits butyrylcholinesterase without side effects on neuromuscular transmissionTomaž Trobec, Monika C. Žužek, Kristina Sepčić, Jerneja Kladnik, Iztok Turel, Robert Frangež, 2023, original scientific article Keywords: organoruthenium(II) complex, acetylcholinesterase, butyrylcholinesterase, mouse neuromuscular system, ruthenium, Alzheimer disease, neurodegenerative diseases
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6. Binding kinetics of ruthenium pyrithione chemotherapeutic candidates to human serum proteins studied by HPLC-ICP-MSKatarina Marković, Radmila Milačič, Stefan Marković, Jerneja Kladnik, Iztok Turel, Janez Ščančar, 2020, original scientific article Keywords: ruthenium-based chemotherapeutics, drug candidates, pyrithione, kinetics study, human serum, speciation analysis, CLC monolithic chromatography, CIM Protein G, DEAE disks, UV spectrometry, isotope dilution inductively coupled plasma mass spectrometry
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7. Comparison of solution chemical properties and biological activity of ruthenium complexes of selected ß-diketone, 8-hydroxyquinoline and pyrithione ligandsTamás Pivarcsik, Gábor Tóth, Nikoletta Szemerédi, Anita Bogdanov, Gabriella Spengler, Jakob Kljun, Jerneja Kladnik, Iztok Turel, Éva A. Enyedy, 2021, original scientific article Keywords: MTT assay, UV-vis, solution stability, MRSA, albumin binding, ligand effect
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9. Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cellsJerneja Kladnik, James P. C. Coverdale, Jakob Kljun, Hilke Burmeister, Petra Lippman, Francesca G. Ellis, Alan M. Jones, Ingo Ott, Isolda Romero-Canelón, Iztok Turel, 2021, original scientific article Keywords: ruthenium, pyrithione, resistance to chemotherapy, cancer, ovarian, thioredoxin
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10. Zinc pyrithione is a potent inhibitor of PL$^{Pro}$ and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replicationJerneja Kladnik, Ana Dolinar, Jakob Kljun, David Perea, Judith Grau-Expósito, Meritxell Genescà, Marko Novinec, Maria J. Buzon, Iztok Turel, 2022, original scientific article Keywords: antiviral agents, SARS-CoV-2, inhibition, pyrithione, zinc
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