1. Recent progress in the discovery and development of DNA gyrase B inhibitorsMichaela Barančokova, Danijel Kikelj, Janez Ilaš, 2018, review article Keywords: antibacterial, ATP-competitive, DNA gyrase, drug discovery, Gram-negative bacteria, GyrB, inhibitor, Par, topoisomerase II, topoisomerase IV Full text (file, 717,37 KB) This document has more files! More... |
2. A fine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIsAnja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: antibacterials, drug discovery, DNA gyrase inhibitors, topoisomerase IV inhibitors, intercalators, novel bacterial topoisomerase inhibitors, topoisomerase II inhibitors, intercalating agents Full text (file, 6,80 MB) This document has more files! More... |
3. Cell models for Alzheimer’s and Parkinson’s diseaseSandra Cetin, Damijan Knez, Stanislav Gobec, Janko Kos, Anja Pišlar, 2022, review article Keywords: neurodegenerative diseases, cell models, cytotoxicity assays, drug discovery, drug screening Full text (file, 1,65 MB) This document has more files! More... |
4. Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesisMatic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec, 2023, original scientific article Keywords: fragment-based drug discovery, hit triage, inhibitors, antibacterial agents Full text (file, 1,79 MB) This document has more files! More... |
5. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bondsAnja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh, 2021, original scientific article Keywords: antibacterials, DNA gyrase inhibitors, drug discovery, Staphylococcus aureus, intercalators, novel bacterial topoisomerase inhibitors, NBTIs, symmetrical bifurcated halogen bonds, crystal structure, novel NBTIs mechanism of action, antimicrobials, DNA-binding proteins, drug development, X-ray crystallography Full text (file, 2,00 MB) This document has more files! More... |
6. Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testingLarisa Tratnjek, Nadica Sibinovska, Slavko Kralj, Darko Makovec, Katja Kristan, Mateja Erdani-Kreft, 2021, original scientific article Keywords: esophageal adenocarcinoma, FLO-1 cell line, disease pathophysiology, biological techniques, cancer, cell biology, diseases, drug discovery, engineering, oncology Full text (file, 16,48 MB) This document has more files! More... |
7. Small-Molecule Galectin Ligands: Structure-Based Optimisation of Affinity and SelectivitySjors Van Klaveren, 2024, doctoral dissertation Keywords: Galectins, ligands, inhibitors, drug discovery, molecular dynamics simulations, virtual screening, docking studies, structure-activity relationship, X-ray crystallography. Full text (file, 20,83 MB) |
8. Biolayer interferometry and its applications in drug discovery and developmentAna Jug, Tomaž Bratkovič, Janez Ilaš, 2024, review article Keywords: biosensor, drug discovery, library screening, label-free analysis, kinetics, affinity, biopharmaceutical development Full text (file, 1,22 MB) This document has more files! More... |