1. Benzamide derivatives targeting the cell division protein FtsZValentina Straniero, Lorenzo Suigo, Andrea Casiraghi, Victor Sebastián-Pérez, Martina Hrast, Carlo Zanotto, Irena Zdovc, Carlo De Giuli Morghen, Antonia Radaelli, Ermanno Valoti, 2020, original scientific article Keywords: cell division protein FtsZ, benzamide, 1, 4-benzodioxane, 1, 4-benzoxathiane, multi-drug resistant Staphylococcus aureus, Escherichia coli N43, veterinary medicine
Full text (file, 6,25 MB) This document has more files! More... |
2. Synthesis and evaluation of antioxidant properties of 2-substituted quinazolin-4(3H)-onesJanez Mravljak, Lara Slavec, Martina Hrast, Matej Sova, 2021, original scientific article Keywords: quinazolinone, synthesis, antioxidant, DPPH, ABTS, CUPRAC, metal-chelating properties
Full text (file, 2,84 MB) This document has more files! More... |
3. Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacyMaja Kokot, Matjaž Weiss, Irena Zdovc, Lidija Senerovic, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast, 2023, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, antibacterials, MRSA, hERG inhibition, in vivo efficacy
Full text (file, 3,61 MB) This document has more files! More... |
|
5. Inhibition of MurA enzyme from Escherichia coli and Staphylococcus aureus by diterpenes from Lepechinia meyenii and their synthetic analogsMacarena Funes Chabán, Martina Hrast, Rok Frlan, Dafni G. Graikioti, Constantinos M. Athanassopoulos, María Cecilia Carpinella, 2021, original scientific article Keywords: dehydroabietane derivatives, diterpenes, MurA inhibitors, MurF inhibitors, Staphylococcus aureus MurA, Escherichia coli MurA
Full text (file, 2,12 MB) This document has more files! More... |
6. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bondsAnja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh, 2021, original scientific article Keywords: antibacterials, DNA gyrase inhibitors, drug discovery, Staphylococcus aureus, intercalators, novel bacterial topoisomerase inhibitors, NBTIs, symmetrical bifurcated halogen bonds, crystal structure, novel NBTIs mechanism of action, antimicrobials, DNA-binding proteins, drug development, X-ray crystallography
Full text (file, 2,00 MB) This document has more files! More... |
7. Targeting N-acetylglucosaminidase in Staphylococcus aureus with iminosugar inhibitorsJanja Sluga, Tihomir Tomašič, Marko Anderluh, Martina Hrast, Gregor Bajc, Alen Sevšek, Nathaniel I. Martin, Roland J. Pieters, Marjana Novič, Katja Venko, 2024, original scientific article Keywords: autolysin E, glycoside hydrolase, iminosugars, surface plasmon resonance, enzyme inhibition
Full text (file, 1,88 MB) This document has more files! More... |
|
|
10. DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathwayMatic Proj, Krištof Bozovičar, Martina Hrast, Rok Frlan, Stanislav Gobec, 2022, original scientific article Keywords: antibacterial agents, DNA-encoded library, screening, inhibitors
Full text (file, 1,04 MB) This document has more files! More... |
