11. Structure-activity relationships of benzothiazole-based Hsp90 C-terminal-domain inhibitorsJaka Dernovšek, Živa Zajec, Martina Durcik, Lucija Peterlin-Mašič, Martina Gobec, Nace Zidar, Tihomir Tomašič, 2021, original scientific article Keywords: allostery, Hsp90, benzothiazole, cancer, inhibitor, cancer therapy Full text (file, 7,92 MB) This document has more files! More... |
12. Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitorsSjors van Klaveren, Jaka Dernovšek, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf Nilsson, Tihomir Tomašič, 2022, original scientific article Full text (file, 1010,75 KB) This document has more files! More... |
13. In silico discovery and optimisation of a novel structural class of Hsp90 C-terminal domain inhibitorsŽiva Zajec, Jaka Dernovšek, Martina Gobec, Tihomir Tomašič, 2022, original scientific article Keywords: allosteric, cancer, heat shock, Hsp90, inhibitor, virtual screening Full text (file, 7,89 MB) This document has more files! More... |
14. New diarylamine KV10.1 inhibitors and their anticancer potentialŠpela Gubič, Žan Toplak, Xiaoyi Shi, Jaka Dernovšek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašič, 2022, original scientific article Keywords: KV10.1, ion channels, hERG, SAR, antiproliferative activity Full text (file, 869,51 KB) This document has more files! More... |
15. Benzimidazole-galactosides bind selectively to the galectin-8 N-terminal domainMujtaba Hassan, Sjors van Klaveren, Maria Håkansson, Carl Diehl, Rebeka Kovačič, Floriane Baussière, Anders Sundin, Jaka Dernovšek, Marko Anderluh, Tihomir Tomašič, Žiga Jakopin, 2021, original scientific article Keywords: benzimidazole, galectin-8N, quinoline, selectivity, molecular dynamics, x-ray crystallography Full text (file, 1,71 MB) This document has more files! More... |
16. Catalytic stereoconvergent synthesis of homochiral β‑CF$_3$, β‑SCF$_3$, and β‑OCF$_3$ benzylic alcoholsAndrej Emanuel Cotman, Pavel A. Dub, Maša Sterle, Matic Lozinšek, Jaka Dernovšek, Živa Zajec, Anamarija Zega, Tihomir Tomašič, Dominique Cahard, 2022, original scientific article Keywords: adaptive crystals, asymmetric catalysis, density functional calculations, drug design, fluorine, hydrogenation, kinetic resolution, ruthenium, alcohols, catalysts, crystals, ketones, stereoselectivity Full text (file, 2,08 MB) This document has more files! More... |
17. Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcomaŽiva Zajec, Jaka Dernovšek, Martin Distel, Martina Gobec, Tihomir Tomašič, 2023, original scientific article Keywords: cancer, Ewing sarcoma, Hsp90, inhibitor, molecular modelling Full text (file, 3,11 MB) This document has more files! More... |
18. Refined high-content imaging-based phenotypic drug screening in zebrafish xenograftsCaterina Sturtzel, Živa Zajec, Jaka Dernovšek, Tihomir Tomašič, Sabine Taschner-Mandl, Martin Distel, 2023, original scientific article Keywords: cancer models, phenotypic screening Full text (file, 5,10 MB) This document has more files! More... |
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