291. Discovery of novel Hsp90 C-terminal inhibitors using 3D-pharmacophores derived from molecular dynamics simulationsTihomir Tomašič, Martina Durcik, Bradley M. Keegan, Darja Gramec, Živa Zajec, Brian S. J. Blagg, Sharon D. Bryant, 2020, original scientific article Keywords: allosteric, cancer, Hsp90, inhibitor, molecular dynamics, pharmacophores, virtual screening
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292. Structure-activity relationships of benzothiazole-based Hsp90 C-terminal-domain inhibitorsJaka Dernovšek, Živa Zajec, Martina Durcik, Lucija Peterlin-Mašič, Martina Gobec, Nace Zidar, Tihomir Tomašič, 2021, original scientific article Keywords: allostery, Hsp90, benzothiazole, cancer, inhibitor, cancer therapy
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293. ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffoldŽiga Skok, Martina Durcik, Živa Zajec, Darja Gramec, Krištof Bozovičar, Anja Pišlar, Tihomir Tomašič, Anamarija Zega, Lucija Peterlin-Mašič, Danijel Kikelj, Nace Zidar, Janez Ilaš, 2023, original scientific article Keywords: anticancer drugs, ATP-competitive inhibitors, catalytic inhibitor, cytotoxicity, human DNA topoisomerase II
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294. In silico discovery and optimisation of a novel structural class of Hsp90 C-terminal domain inhibitorsŽiva Zajec, Jaka Dernovšek, Martina Gobec, Tihomir Tomašič, 2022, original scientific article Keywords: allosteric, cancer, heat shock, Hsp90, inhibitor, virtual screening
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295. Catalytic stereoconvergent synthesis of homochiral β‑CF$_3$, β‑SCF$_3$, and β‑OCF$_3$ benzylic alcoholsAndrej Emanuel Cotman, Pavel A. Dub, Maša Sterle, Matic Lozinšek, Jaka Dernovšek, Živa Zajec, Anamarija Zega, Tihomir Tomašič, Dominique Cahard, 2022, original scientific article Keywords: adaptive crystals, asymmetric catalysis, density functional calculations, drug design, fluorine, hydrogenation, kinetic resolution, ruthenium, alcohols, catalysts, crystals, ketones, stereoselectivity
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296. Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcomaŽiva Zajec, Jaka Dernovšek, Martin Distel, Martina Gobec, Tihomir Tomašič, 2023, original scientific article Keywords: cancer, Ewing sarcoma, Hsp90, inhibitor, molecular modelling
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297. Refined high-content imaging-based phenotypic drug screening in zebrafish xenograftsCaterina Sturtzel, Živa Zajec, Jaka Dernovšek, Tihomir Tomašič, Sabine Taschner-Mandl, Martin Distel, 2023, original scientific article Keywords: cancer models, phenotypic screening
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