1. A set of experimentally validated decoys for the human CC chemokine receptor 7 (CCR7) obtained by virtual screeningMatic Proj, Steven De Jonghe, Tom Van Loy, Marko Jukič, Anže Meden, Luka Ciber, Črtomir Podlipnik, Uroš Grošelj, Janez Konc, Dominique Schols, Stanislav Gobec, 2022, original scientific article Keywords: virtual screening, decoys, chemical library, computer-aided drug design, CCR7, GPCR Full text (file, 2,30 MB) This document has more files! More... |
2. Redox active or thiol reactive?Matic Proj, Damijan Knez, Izidor Sosič, Stanislav Gobec, 2022, review article Keywords: redox, covalent, screening, hits, PAINS, assays Full text (file, 1,04 MB) This document has more files! More... |
3. New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicityAna Mitrović, Emanuela Senjor, Marko Jukič, Lara Bolčina, Mateja Prunk, Matic Proj, Milica Perišić, Stanislav Gobec, Janko Kos, 2022, original scientific article Keywords: cathepsin V, small-molecule inhibitors, antitumor therapy, cancer, cystatin F Full text (file, 3,84 MB) This document has more files! More... |
4. Sinteza in vrednotenje novih zaviralcev iondolamin 2,3-dioksigenaze 1, odkritih s pomočjo virtualnega rešetanja na osnovi struktur liganda in encimaMatic Proj, 2018, master's thesis Keywords: sintezni postopki, virtualno repetanje, indolamin 2, 3-dioksigenaza, zaviralci IDO1, metode, imunoterapija Full text (outside link) |
5. Fragment-sized and bidentate (immuno)proteasome inhibitors derived from cysteine and threonine targeting warheadsLevente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Stanislav Gobec, Izidor Sosič, György Keserü M., 2021, original scientific article Keywords: immunoproteasome, benzoxazole-2-carbonitriles, bidentate covalent inhibitors, fragments, non-covalent recognition Full text (file, 1,17 MB) This document has more files! More... |
6. DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathwayMatic Proj, Krištof Bozovičar, Martina Hrast, Rok Frlan, Stanislav Gobec, 2022, original scientific article Keywords: antibacterial agents, DNA-encoded library, screening, inhibitors Full text (file, 1,04 MB) This document has more files! More... |
7. Discovery of immunoproteasome inhibitors using large-scale covalent virtual screeningAndrea Scarpino, Dávid Bajusz, Matic Proj, Martina Gobec, Izidor Sosič, Stanislav Gobec, György G. Ferenczy, György Keserü M., 2019, original scientific article Keywords: immunoproteasome, covalent inhibitor, virtual screening, β5i selective inhibitor Full text (file, 3,77 MB) This document has more files! More... |
8. Synthesis and biochemical evaluation of warhead-decorated psoralens as (immuno)proteasome inhibitorsEva Shannon Schiffrer, Matic Proj, Martina Gobec, Luka Rejc, Andrej Šterman, Janez Mravljak, Stanislav Gobec, Izidor Sosič, 2021, original scientific article Keywords: immunoproteasome, psoralen core, non-peptidic, electrophilic compounds, warhead scan Full text (file, 3,29 MB) This document has more files! More... |
9. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warheadKatarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György Keserü M., Stanislav Gobec, 2022, original scientific article Keywords: antibacterial agents, UDP-N-acetylglucosamine enolpyruvyl transferase, thiol reactivity Full text (file, 4,05 MB) This document has more files! More... |
10. Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesisMatic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec, 2023, original scientific article Keywords: fragment-based drug discovery, hit triage, inhibitors, antibacterial agents Full text (file, 1,79 MB) This document has more files! More... |