1. Bromo-cyclobutenaminones as new covalent UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) inhibitorsDavid J. Hamilton, Péter Ábrányi-Balogh, Aaron Keeley, László Petri, Martina Hrast, Tímea Imre, Maikel Wijtmans, Stanislav Gobec, Iwan J. P. de Esch, György Keserü M., 2020, original scientific article Keywords: covalent inhibitor, MurA, cyclobutenaminone, antibacterial, irreversible Full text (file, 1,08 MB) This document has more files! More... |
2. Fragment-sized and bidentate (immuno)proteasome inhibitors derived from cysteine and threonine targeting warheadsLevente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Stanislav Gobec, Izidor Sosič, György Keserü M., 2021, original scientific article Keywords: immunoproteasome, benzoxazole-2-carbonitriles, bidentate covalent inhibitors, fragments, non-covalent recognition Full text (file, 1,17 MB) This document has more files! More... |
3. Discovery of immunoproteasome inhibitors using large-scale covalent virtual screeningAndrea Scarpino, Dávid Bajusz, Matic Proj, Martina Gobec, Izidor Sosič, Stanislav Gobec, György G. Ferenczy, György Keserü M., 2019, original scientific article Keywords: immunoproteasome, covalent inhibitor, virtual screening, β5i selective inhibitor Full text (file, 3,77 MB) This document has more files! More... |
4. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warheadKatarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György Keserü M., Stanislav Gobec, 2022, original scientific article Keywords: antibacterial agents, UDP-N-acetylglucosamine enolpyruvyl transferase, thiol reactivity Full text (file, 4,05 MB) This document has more files! More... |
5. Next-generation heterocyclic electrophiles as small-molecule covalent MurA inhibitorsPéter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György Keserü M., 2022, original scientific article Keywords: covalent inhibitor, heterocyclic electrophiles, cysteine labelling, quaternization, MurA Full text (file, 1,46 MB) This document has more files! More... |