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4. Design of new potent and selective thiophene-based K$_V$1.3 inhibitors and their potential for anticancer activityŠpela Gubič, Žan Toplak, Štefan Možina, Tihomir Tomašič, Lucija Peterlin-Mašič, 2022, original scientific article Keywords: K$_V$1.3, potassium ion channels, antiproliferative activity, apoptosis, anticancer drugs Full text (file, 10,07 MB) This document has more files! More... |
5. 3D pharmacophore-based discovery of novel Kv10.1 inhibitors with antiproliferative activityŽan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin-Mašič, 2021, original scientific article Keywords: K$_V$10.1, ion channels, hERG, pharmacophore modelling, virtual screening, antiproliferative activity Full text (file, 14,79 MB) This document has more files! More... |
6. Discovery of K$_V$1.3 ion channel inhibitorsŠpela Gubič, Louise Antonia Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašič, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija Peterlin-Mašič, 2021, review article Keywords: K$_V$1.3 channel, design of K$_V$1.3 inhibitors, mitochondrial K$_V$1.3, peptide inhibitors, small-molecule inhibitors Full text (file, 6,21 MB) This document has more files! More... |
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8. New diarylamine KV10.1 inhibitors and their anticancer potentialŠpela Gubič, Žan Toplak, Xiaoyi Shi, Jaka Dernovšek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašič, 2022, original scientific article Keywords: KV10.1, ion channels, hERG, SAR, antiproliferative activity Full text (file, 869,51 KB) This document has more files! More... |
9. Immunosuppressive effects of new thiophene-based K$_V$1.3 inhibitorsŠpela Gubič, Janez Ilaš, Tihomir Tomašič, Annarosa Arcangeli, Lucija Peterlin-Mašič, 2023, original scientific article Keywords: ion channel, K$_V$1.3 inhibitor, T-lymphocyte, immunosuppressive Full text (file, 2,73 MB) This document has more files! More... |