1. Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitorsŽiga Jakopin, Janez Ilaš, Michaela Barančokova, Matjaž Brvar, Päivi Tammela, Marija Sollner Dolenc, Tihomir Tomašič, Danijel Kikelj, 2017, original scientific article Keywords: 1, 2, 4-oxadiazoles, DNA gyrase inhibition, topoisomerase IV inhibition, antibacterial screening, computer-aided drug design Full text (file, 1,45 MB) This document has more files! More... |
2. Recent progress in the discovery and development of DNA gyrase B inhibitorsMichaela Barančokova, Danijel Kikelj, Janez Ilaš, 2018, review article Keywords: antibacterial, ATP-competitive, DNA gyrase, drug discovery, Gram-negative bacteria, GyrB, inhibitor, Par, topoisomerase II, topoisomerase IV Full text (file, 717,37 KB) This document has more files! More... |
3. Simulation- and AI-directed optimization of 4,6-substituted 1,3,5-triazin-2(1H)-ones as inhibitors of human DNA topoisomerase IIαBarbara Herlah, Tjaša Goričan, Nika Strašek Benedik, Simona Golič Grdadolnik, Izidor Sosič, Andrej Perdih, 2024, original scientific article Keywords: molecular design, molecular simulations, deep learning, human DNA, topoisomerase IIα, catalytic inhibitors, anticancer agents Full text (file, 10,65 MB) This document has more files! More... |
4. A fine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIsAnja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: antibacterials, drug discovery, DNA gyrase inhibitors, topoisomerase IV inhibitors, intercalators, novel bacterial topoisomerase inhibitors, topoisomerase II inhibitors, intercalating agents Full text (file, 6,80 MB) This document has more files! More... |
5. Selective DNA gyrase inhibitorsTihomir Tomašič, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant, 2021, original scientific article Keywords: antibacterial, ATP-competitive, DNA gyrase, Hsp90, pharmacophore model, topoisomerase II, target activity profiling, topoisomerase IIα Full text (file, 6,96 MB) This document has more files! More... |
6. Structurally optimized potent dual-targeting NBTI antibacterials with an enhanced bifurcated halogen-bonding propensityMaja Kokot, Matjaž Weiss, Irena Zdovc, Martina Hrast, Marko Anderluh, Nikola Minovski, 2021, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, bifurcated halogen bonds, dual targeting Full text (file, 2,92 MB) This document has more files! More... |
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8. Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitorsŽiga Skok, Michaela Barančokova, Ondřej Benek, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašič, Nace Zidar, Lucija Peterlin-Mašič, Anamarija Zega, Danijel Kikelj, Janez Ilaš, 2020, original scientific article Keywords: DNA gyrase, topoisomerase IV, GyrB, ParE, antibacterial benzothiazole Full text (file, 2,22 MB) This document has more files! More... |
9. Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacyMaja Kokot, Matjaž Weiss, Irena Zdovc, Lidija Senerovic, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast, 2023, original scientific article Keywords: NBTIs, DNA gyrase, topoisomerase IV, antibacterials, MRSA, hERG inhibition, in vivo efficacy Full text (file, 3,61 MB) This document has more files! More... |
10. ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffoldŽiga Skok, Martina Durcik, Živa Zajec, Darja Gramec, Krištof Bozovičar, Anja Pišlar, Tihomir Tomašič, Anamarija Zega, Lucija Peterlin-Mašič, Danijel Kikelj, Nace Zidar, Janez Ilaš, 2023, original scientific article Keywords: anticancer drugs, ATP-competitive inhibitors, catalytic inhibitor, cytotoxicity, human DNA topoisomerase II Full text (file, 2,83 MB) This document has more files! More... |