Membrane localization of Piezo1 in the context of its role in the regulation of red blood cell volume

Božič, Bojan (avtor), Svetina, Saša (avtor)

Piezo1 is a membrane nonspecific cation channel involved in red blood cells (RBCs) in the regulation of their volume. Recently, it was shown that it is distributed on the RBC membrane in a nonuniform manner. Here it is shown that it is possible to interpret the lateral distribution of Piezo1 molecules on RBC membrane by the curvature dependent Piezo1—bilayer interaction which is the consequence of the mismatch between the intrinsic principal curvatures of the Piezo1 trimer and the principal curvatures of the membrane at Piezo1's location but without its presence. This result supports the previously proposed model for the role of Piezo1 in the regulation of RBC volume.

• Jezik: Angleški jezik
• Ključne besede: red blood cell volume, membrane permeability, discocyte, lateral distribution, membrane curvature, channel, intrinsic curvature, spontaneous curvature
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 8 str.
• Številčenje: Vol. 13, art. 879038
• PID: 20.500.12556/RUL-145376
• UDK: 616.1
• ISSN pri članku: 1664-042X
• DOI: 10.3389/fphys.2022.879038
• COBISS.SI-ID: 110843139
• Datum objave v RUL: 19.04.2023

Gradivo je del revije

• Naslov: Frontiers in physiology
• Skrajšan naslov: Front. physiol.
• Založnik: Frontiers Research Foundation
• ISSN: 1664-042X
• COBISS.SI-ID: 1218939

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: volumen rdečih krvnih celic, prepustnost membrane, diskocit

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0055
• Naslov: Biofizika polimerov, membran, gelov, koloidov in celic