Membrane localization of Piezo1 in the context of its role in the regulation of red blood cell volume

Božič, Bojan (author), Svetina, Saša (author)

Piezo1 is a membrane nonspecific cation channel involved in red blood cells (RBCs) in the regulation of their volume. Recently, it was shown that it is distributed on the RBC membrane in a nonuniform manner. Here it is shown that it is possible to interpret the lateral distribution of Piezo1 molecules on RBC membrane by the curvature dependent Piezo1—bilayer interaction which is the consequence of the mismatch between the intrinsic principal curvatures of the Piezo1 trimer and the principal curvatures of the membrane at Piezo1's location but without its presence. This result supports the previously proposed model for the role of Piezo1 in the regulation of RBC volume.

• Language: English
• Keywords: red blood cell volume, membrane permeability, discocyte, lateral distribution, membrane curvature, channel, intrinsic curvature, spontaneous curvature
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 8 str.
• Numbering: Vol. 13, art. 879038
• PID: 20.500.12556/RUL-145376
• UDC: 616.1
• ISSN on article: 1664-042X
• DOI: 10.3389/fphys.2022.879038
• COBISS.SI-ID: 110843139
• Publication date in RUL: 19.04.2023

Record is a part of a journal

• Title: Frontiers in physiology
• Shortened title: Front. physiol.
• Publisher: Frontiers Research Foundation
• ISSN: 1664-042X
• COBISS.SI-ID: 1218939

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: volumen rdečih krvnih celic, prepustnost membrane, diskocit

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0055
• Name: Biofizika polimerov, membran, gelov, koloidov in celic