Integration of androgen hormones in endometrial cancer biology

Gjorgoska, Marija (avtor), Lanišnik-Rižner, Tea (avtor)

Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving mutational landscapes of endometrial tumors that hold great potential for tailoring therapeutic strategies. This review aims to broaden our knowledge of EC biology by focusing on the role of androgen hormones. First, we discuss epidemiological evidence implicating androgens with EC pathogenesis and cover their biosynthesis and metabolism to bioactive 11-oxyandrogens. Next, we explore the endometrial tumor tissue and the altered microbiota as alternative sources of androgens and their 11-oxymetabolites in EC patients. Finally, we discuss the biological significance of androgens' genomic and nongenomic signaling as part of a medley of pathways ultimately deciding the fate of cells.

• Jezik: Angleški jezik
• Ključne besede: endocrinology, endometrial cancer, androgen hormones, androgen receptor, androgens, androgen signaling, molecular targeted therapy, 11-oxyandrogens
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: Str. 639-651
• Številčenje: Vol. 33, no. 9
• PID: 20.500.12556/RUL-145191
• UDK: 618.1
• ISSN pri članku: 1043-2760
• DOI: 10.1016/j.tem.2022.06.001
• COBISS.SI-ID: 116172547
• Datum objave v RUL: 13.04.2023

Gradivo je del revije

• Naslov: Trends in endocrinology and metabolism
• Skrajšan naslov: Trends endocrinol. metab.
• Založnik: Elsevier
• ISSN: 1043-2760
• COBISS.SI-ID: 1191188

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: endokrinologija, rak endometrija, androgeni hormoni

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-2535
• Naslov: Vloga androgenov pri hormonsko odvisnih boleznih: pomen za diagnostiko in zdravljenje